Comprehensive Handbook For Pediatric Hepatology And Liver Disease Management: Liver Physiology, Hepatobiliary Disorders, Diagnostic Evaluation, ... Care (Comprehensive Clinical Medicine Series) - Couverture souple

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9798177610009: Comprehensive Handbook For Pediatric Hepatology And Liver Disease Management: Liver Physiology, Hepatobiliary Disorders, Diagnostic Evaluation, ... Care (Comprehensive Clinical Medicine Series)

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ISBN 13 : 9798177610009

Editeur : Independently published, 2026

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Comprehensive Handbook for Pediatric Hepatology and Liver Disease Management provides an in-depth exploration of pediatric liver physiology, hepatobiliary disorders, diagnostic evaluation, medical treatment, surgery, transplantation, and long-term multidisciplinary care. Designed as both an advanced academic reference and a practical clinical resource, this handbook brings together the fundamental science and clinical reasoning required to understand the complex spectrum of liver disease encountered throughout childhood.

Beginning with the development, anatomy, metabolism, bile formation, bilirubin processing, inflammation, fibrosis, and regenerative capacity of the pediatric liver, the book establishes a strong physiological foundation before progressing into clinical assessment and diagnostic interpretation. Readers are guided through laboratory evaluation, ultrasonography, Doppler imaging, elastography, CT, MRI, MRCP, liver biopsy, genetic testing, genomic sequencing, and modern molecular diagnostic strategies.

Major pediatric hepatobiliary disorders are examined in detail, including neonatal jaundice, conjugated hyperbilirubinemia, biliary atresia, choledochal cysts, progressive familial intrahepatic cholestasis, Alagille syndrome, bile acid synthesis defects, metabolic liver diseases, glycogen storage disorders, Wilson disease, alpha-1 antitrypsin deficiency, viral hepatitis, autoimmune hepatitis, autoimmune sclerosing cholangitis, metabolic dysfunction-associated steatotic liver disease, drug-induced liver injury, cirrhosis, portal hypertension, vascular disorders, and pediatric acute liver failure.

The handbook also provides extensive coverage of hepatic encephalopathy, nutrition and growth failure, fat-soluble vitamin deficiencies, pediatric liver tumors, hepatoblastoma, hepatocellular carcinoma, hepatobiliary surgery, interventional radiology, portal-hypertension procedures, and biliary reconstruction.

Beyond traditional hepatology, the book explores the rapidly developing future of the specialty, including genomic medicine, molecular classification, gene therapy, RNA-based treatments, targeted therapies for inherited cholestatic and metabolic diseases, artificial intelligence, advanced imaging, predictive biomarkers, organoids, regenerative medicine, machine perfusion, and emerging transplant technologies.

Every chapter is strengthened with learning objectives, key terms, detailed clinical discussions, tables, image concepts, clinical case studies, advanced clinical scenario questions with answers, clinical pearls, practice tips, and concise chapter summaries. Three practical appendices provide additional support for laboratory interpretation, diagnostic algorithms, emergency warning signs, transplantation monitoring, and lifelong pediatric liver care.

This handbook is especially useful for:

1. Pediatric hepatologists and gastroenterologists
2. Pediatricians
3. Pediatric and transplant surgeons
4. Liver transplant professionals
5. Medical students and residents
6. Gastroenterology and hepatology fellows
7. Nurse practitioners and physician assistants
8. Dietitians and allied health professionals
9. Clinical researchers and academic institutions

Whether used for advanced study, clinical reference, teaching, or professional development, Comprehensive Handbook for Pediatric Hepatology and Liver Disease Management provides a structured and wide-ranging resource for understanding the biological mechanisms, diagnostic challenges, therapeutic strategies, and lifelong care needs of children with liver and hepatobiliary disease.