Advancing Personalized Medicine With AI-Driven Microbiome and Nutrigenomics: Innovations and Future Perspectives

Health and disease are increasingly understood through the lens of interconnected biological systems shaped by host genetics, microbial ecology, nutritional inputs, metabolic regulation, and environmental exposures. Advances in multi-omics technologies and artificial intelligence have accelerated the ability to examine these systems at high resolution, revealing previously obscured patterns that govern immune equilibrium, metabolic stability, and long-term disease susceptibility. As global burdens of cancer, diabetes, inflammatory disorders, and environmental toxicity continue to rise, there is an urgent need for integrative frameworks that move beyond reductionist models and toward predictive, preventive, and personalized approaches. Advancing Personalized Medicine with AI-Driven Microbiome and Nutrigenomics: Innovations and Future Perspectives presents a comprehensive systems-level exploration anchored in the polybiome framework-a model that unifies microbial fermentomics, nutrigenomic modulation, immunometabolic regulation, and environmental interactions. The volume introduces NexDi, an AI-enabled diabetes reclassification system based on extensive cohort data, illustrating how multi-omics integration can predict metabolic instability and ß-cell vulnerability before clinical manifestation. Additional chapters extend this framework to oncological microenvironments, immune-microbial signaling networks, precision nutrition algorithms, engineered microbial consortia, and ethical governance in AI-driven healthcare. This reference is designed for researchers, clinicians, data scientists, and policymakers seeking rigorous methodologies and translational insights to advance personalized medicine, chronic disease prevention, and biointelligent health systems.

Dr. Reyed M. Reyed is an Associate Professor of Microbial Biotechnology with a distinguished career spanning microbial genomics, computational enzymes, environmental sustainability, and precision health research. He is affiliated with the Genetic Engineering and Biotechnology Research Institute (GEBRI) at the City for Scientific Research and Technological Applications (SRTA-CITY), Egypt. Academic Background and International Recognitions Dr. Reyed earned his PhD in Microbiology in 2005 from the prestigious Al-Farabi Kazakh National University, Faculty of Biological Sciences, Kazakhstan. His early academic achievements were recognized when he received the Best Young Scientist Award from the same university in 2003. His expertise in bioinformatics and computational biology was further enhanced during his fellowship at the Institute of Bioinformatics and Biochemistry, Centre for Biological Sciences in Bangalore, India (2006-2007). Entrepreneurship and Bioinformatics Leadership His entrepreneurial acumen is evidenced by his Certificate in Entrepreneurship from the Knowledge Project, undertaken in collaboration with the United Nations Development Corporation and the Mohammed bin Rashid Al Maktoum Foundation for Knowledge, along with advanced studies at the Copenhagen Business School. He is also actively involved in H3ABioNet, a Pan-African Bioinformatics network, further demonstrating his commitment to global bioinformatics advancements. Cutting-Edge Research and International Contributions Dr. Reyed is deeply engaged in genetic nutrition and bioinformatics, having completed specialized courses at the European Bioinformatics Institute (EMBL-EBI) and attended workshops supported by grants from the European Union and the International Centre for Genetic Engineering and Biotechnology (ICGEB), Italy. His expertise in genome editing was solidified through his participation in a workshop on CRISPR/Cas9 Genome Editing at Helwan University's Faculty of Pharmacy. He has also been awarded a grant from Sandia National Laboratories, USA, enabling him to participate in the Biosafety Conference in Bangkok, Thailand (2007), where he delivered lectures at the Division of Biotechnology, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi (KMUTT), Thailand. PRESENTATION and PUBLIC LECTURE: International and national lectures 1. Imbalance of Human Gut Microecology and the revolution of probiotics, 29.03.2008, Science Club with cooperation with Molecular Biology Units, Department of Botany, Faculty of Science, Banha University, Benha. Egypt. 2. Microbiology at present time "journey within us microbiological view for human gut Microecology" 20.02.2008, The Russian Center for Science and Culture, Alexandria, Egypt. 3. BREAST-FEEDING AND HEALTHY MICROECOLOGY IN THE GUT"MICROBIOLOGICAL VIEW WITH UNIQUE SCIENTIFIC EVIDENCE", 21.11.2007, Science Club, Faculty of Science, Banha University, Benha. Egypt . 4. Encapsulation of probiotics "Concept and application development". 18.04.2007. Division of Biotechnology, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi (KMUTT), ToongKru, Bangkok 10140, Thailand. 5. "The impact of probiotics on human gut health" 09.02.2007. Pediatrics Department, Bangalore Baptist Hospital, Bangalore, India. 6. Probiosis and Disbacterosis, 22.12.2006, Department of Microbiology, All India institute of Medical sciences, An sari Nagar, New Delhi, 110029, India. 7. "Biotechnology of probiotics Promising and challenging In industrial application" 10-10-2006 National Centre for Biological Sciences, Tata Institute of Fundamental Research, GKVK, Bellary Road, Bangalore 560065, India. Global Scientific Engagements and Leadership Dr. Reyed is actively involved in international research collaborations, particularly in water treatment and microbiome science. From 2008 to 2019, he specialized in marine biofouling and reverse osmosis systems, addressing critical challenges in water sustainability. Between 2020 and 2023, he led the Egyptian-Indian joint project on water treatment, collaborating with Dr. Asifa Qureshi at CSIR-National Environmental Engineering Research Institute (CSIR-NEERI), India. In 2024, Dr. Reyed received a waived registration grant to attend the IUMS Congress in Florence, Italy (October 23-25, 2024), where he will present on food safety, microbiology, bioinformatics, and open data access for One-Health under the theme "Microorganisms for Sustainable Solutions: Environmental & Clinical Implementations." Key Upcoming Events and Achievements in 2024 - Precision Medicine Exhibition & Summit (Dubai World Trade Center, UAE, May 8-9, 2024) o Ranked #1 in both 'AI in Precision Medicine' and 'Lifestyle Intervention & Disease Prevention' categories. - Illumina's Cancer Genomics Summit (Dubai, May 7, 2024) - Invited speaker. - Drug Discovery, Delivery, and Therapeutics Conference (NYU Abu Dhabi Institute, May 6-8, 2024). - 8th International Conference on Genetic Disorders (Dubai, May 26-30, 2024) - Member of the Research Evaluation Committee. Scientific Editorial Roles and International Reviewing Dr. Reyed holds prestigious editorial positions, including: - Editor-in-Chief of the Journal of Climate Change and Renewable Energy. - Lead editor IGI Global Scientific Publishing - Lead editor Bentham Science Publishers - Academic Editor for Springer Nature - International Journal of Environment and Climate Change https: //journalijecc.com - Reviewer for high-impact journals, including: o European Journal of Nutrition o B. SNF Swedish Nutrition Foundation o Cureus Journal of Medical Science o Microbiology Research Journal International o Journal of Advances in Microbiology o Plant Cell Biotechnology and Molecular Biology o Food and Health Contributions to Clinical Nutrition and Public Health Dr. Reyed is certified in clinical nutrition, having completed training at Baheya Hospital for Breast Cancer Treatment (Code B N 0458) in collaboration with Medix Foundation for Training and Medical Education. He is: - A Registered Clinical Nutritionist with the Egyptian Syndicate of Scientific Professions (No. 44320/6068). - A Registered Physical and Health Nutritionist with the Egyptian Professional Syndicate Committee for Specialists in Cosmetic Professions and Health Services (No. 900444). Community Engagement and Volunteer Work Beyond research, Dr. Reyed is an active volunteer in the UAE, holding multiple licenses, including: - General Volunteer No. 523273 (Abu Dhabi) - Sharjah Volunteer Center No. 61318 - Member of the Egyptian Red Crescent (No. 1352) - Member of the General Syndicate of Egyptian Ambulance Workers (No. 2283) With a career that seamlessly integrates cutting-edge research, academic leadership, and global sustainability initiatives, Dr. Reyed continues to be a driving force in microbial biotechnology, computational bioinformatics, and precision health research.

Pranav Kumar Prabhakar is currently working as Professor and Head at Research and Development Cell, Lovely Professional University, Punjab, India. He is one among the World's Top 2% Scientists (list published by Stanford University, USA, 2021 and 2022). He has completed his Ph.D. in Biotechnology from IIT Madras. His main area of research interest focuses on elucidating molecular mechanism and strategies for oral insulin delivery and mimics the signaling pathways in metabolic disorders (diabetes) with natural products. He is Member of Royal Society of Chemistry, and Asia-Pacific Chemical, Biological & Environmental Engineering Society. He is also serving as Editorial Board Member and Reviewer for many reputed national and international journals. He received honors and is Recipient of travel grant toward attending ATTD 2009 in Greece from Indian Institute of Technology Madras & Council for Scientific and Industrial Research (CSIR) and approved by Department of Science and Technology (DST). He has published 75+ research articles in journals, authored 3 books, and 14 chapters. He also delivered 9 oral and poster presentations in scientific meeting.

A. K. Haghi, Ph.D., is a retired professor and has written, co-written, edited or co-edited more than 1000 publications, including books, book chapters, and papers in refereed journals with over 4000 citations and h-index of 33, according to Google Scholar database. He was appointed as Honorary Research Associate (HRA) of Bioprocesses and Bioproducts Group, Facultad de Ciencias Químicas, Universidad Autónoma de Coahuila, Saltillo, Coahuila, México. He has also been appointed as Honorary Research Associate (HRA) at Chemistry Centre, University of Coimbra, Portugal and held a Senior Research Fellowship (SRF) at the Tbilisi State University. He has supervised several PhD and MSc theses at the University of Guilan and co-supervised international doctoral projects. Professor Haghi holds a BSc in urban and environmental engineering from the University of North Carolina (USA) and holds two MSc, one in mechanical engineering from North Carolina State University (USA) and another one in applied mechanics, acoustics, and materials from the Université de Technologie de Compiègne (France). He was awarded a PhD in engineering sciences at Université de Franche-Comté (France). Professor Haghi is a frequent speaker to national and international audiences. He is the Founder and former Editor-in-Chief of the International Journal of Chemoinformatics and Chemical Engineering and Polymers Research Journal. He has acted as an editorial board member of many international journals and is a persistent reviewer of leading international journals.