Airways Smooth Muscle: Development, and Regulation of Contractility

David Raeburn

ISBN 10: 3034874103 / ISBN 13: 9783034874106

Edité par Springer, Basel, Birkhäuser Basel, Birkhäuser Jun 2012, 2012

A propos de cet article

This item is printed on demand - it takes 3-4 days longer - Neuware -Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent obser vations of the long-term plasticity of this system, i. e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes. There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles. However, the questions posed about trophic interactions dur ing development apply as much to airways smooth muscle neuroeffector systems as to other autonomic neuroeffector systems. These are: i) How do developing nerve fibres know where to go and how do they reach their target sites ii) What determines the density and pattern of inner vation at reaching the effector iii) How do the nerves survive and maintain their position once established iv) What factors influence neurochemical differentiation such that genetically multipotential neu rones are triggered to synthesize one or combinations of neurotransmit ters v) What influence do nerves have on the structure, function and receptor expression of their effector cells vi) How do diseases interrupt these processes - see [1]. 424 pp. Englisch.

N° de réf. du vendeur 9783034874106

Détails bibliographiques

• Titre: Airways Smooth Muscle: Development, and Regulation of Contractility
• Éditeur: Springer, Basel, Birkhäuser Basel, Birkhäuser Jun 2012
• Date de parution: 2012
• Langue: anglais
• ISBN à 10 chiffres: 3034874103
• ISBN à 13 chiffres: 9783034874106
• Reliure: Taschenbuch
• État de l'article: Neu
• Dimensions: 244 L x 170 H x 23 P (en millimètres) 244 millimètres de largeur par 170 millimètres de hauteur par 23 millimètres de profondeur
• Poids: 748 grammes

A propos de ce titre

Synopsis

Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent obser- vations of the long-term plasticity of this system, i. e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes. There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles. However, the questions posed about trophic interactions dur- ing development apply as much to airways smooth muscle neuroeffector systems as to other autonomic neuroeffector systems. These are: i) How do developing nerve fibres know where to go and how do they reach their target sites? ii) What determines the density and pattern of inner- vation at reaching the effector? iii) How do the nerves survive and maintain their position once established? iv) What factors influence neurochemical differentiation such that genetically multipotential neu- rones are triggered to synthesize one or combinations of neurotransmit- ters? v) What influence do nerves have on the structure, function and receptor expression of their effector cells? vi) How do diseases interrupt these processes? - see [1].