Alzheimer: 100 Years and Beyond (Research and Perspectives in Alzheimer's Disease)

Hardcover, xxxiii + 543 pages, illustrated, NOT ex-library. A clean copy with unmarked text, free of inscriptions and stamps. Issued without a dust jacket. Contents: Alois Alzheimer [Concerning a unique disease of the cerebral cortex; History of Alzheimer's first case Auguste D; Alzheimer & beginnings of research into Alzheimer's disease; Alzheimer & the myth of the pioneer]; Beginning of modern research [Alzheimer's Disease at mid-Century; Alzheimer's disease research]; Anatomy & Neuropsychology [Anatomical changes underlying dementia in Alzheimer's disease; Staging of cortical neurofibrillary inclusions of the Alzheimer's type; Of stains & brains: how microscopic & clinical observations contributed to the understanding of Alzheimer's disease; Presenile forms of Alzheimer's disease in 2006]; Cholinergic Deficit [Acetylcholine in AD: Expectations meet reality]; Amyloid & Genetics [Discovery of [Beta] Amyloid; Pathways to the discovery of the neuronal origin & proteolytic biogenesis of A[Beta] amyloid of Alzheimer's disease; Amyloid Hypothesis: history & alternatives; Segregation of a missense mutation in the amyloid [Beta]-protein precursor gene with familial Alzheimer's disease; From the amyloid [Beta] protein (A4) to isolation of the first Alzheimer's disease gene: amyloid [Beta] (A4) precursor protein (APP); Commentary on "Correlative memory deficits, A[Beta] elevation & amyloid plaques in transgenic mice"; Vision for the future: pathogenesis, models & experimental therapeutics; PS1, PS2 & APP mutations that cause Alzheimer's disease increase A[Beta]42; Amyloid precursor protein, AD & Down's syndrome; Catabolism of amyloid [Beta] peptide & pathogenesis of sporadic Alzheimer's disease; Synaptic activity, amyloid-[Beta] & AD; Molecular pathogenesis of AD in human peripheral cells: platelets show it all; Neuronal origin hypothesis of cerebral amyloid angiopathy; Neuropathologist & Alzheimer genetics; Genetics, molecular biology & animal modeling of AD; Genetic Alzheimer-frontotemporal dementia spectrum; Mutation of the AD amyloid gene in hereditary cerebral hemorrhage, Dutch type; Physiological generation of Amyloid [Beta]-peptide & its Consequences for AD Research; Activation of [Alpha]-secretase as an approach for treatment of AD; Challenges to the enigma of [gamma]-secretase & to AD; Targeting [gamma]-Secretase; Presenilin/gamma-secretase complex & its potential as a drug target; Identification of [Beta]-secretase]; ApoE [Apolipoprotein E & AD; Apolipoprotein E4: From synaptic remodeling to genetic risk factor in both familial & sporadic AD]; Tau [Alzheimer tangle: 100 years on; Immunological demonstration of tau protein in nearofibrillary tangles; Bulk isolation of neurofibrillary tangles & discoveries of tau & its abnormal hyperphosphorylation; Natural & molecular history of AD; Tau focused drug discovery for AD & related Neurodegenerative Tauopathies; Ubiquitin is a component of paired helical filaments; Influence of tau on neuronal traffic mechanisms; Search for structure of tau & paired helical filaments]; Oxidative Stress [Changing landscape of AD: From Insoluble to Soluble & from Pathogen to Protector; Molecular & cellular pathways towards and away from AD]; Epidemiology [Paquid]; Imaging [Hippocampal imaging in the early diagnosis of AD 1988 to 2006; Detecting Early-Stage AD in MCI & PreMCI; Imaging the pathology of AD: Building on a century-Old blueprint]; Therapeutical Perspectives [How do we test drugs; Inflammation & lesions of AD; A[Beta] immunotherapy prevents & Reverses AD neuropathology; Immunotherapy; "Magic" bullets, shotguns or cocktails to treat or prevent AD?; Seventh age of man: Solving senility]; Forum & Network [Fondation Ipsen & AD: a 20-year relationship; Alzheimer Research Forum: A Knowledge Base and e-Community for AD Research; Potamkin prize for research in Pick's, Alzheimer's and related diseases]; Subject Index.…