Bioanalytical Investigation:Management of Hypertension Using Doxazosin: Doxazosin using internal standard doxazosin D8 by LC/MS/MS system used in the management of hypertension

Anil Kumar Sahdev

ISBN 10: 3330074833 / ISBN 13: 9783330074835

Edité par LAP LAMBERT Academic Publishing, 2017

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168 pages. 8.66x5.91x0.38 inches. In Stock. N° de réf. du vendeur 3330074833

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Titre : Bioanalytical Investigation:Management of ...

Éditeur : LAP LAMBERT Academic Publishing

Date d'édition : 2017

Reliure : Paperback

Etat : Brand New

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Synopsis :

Development in the bioanalytical technology & the application of pharmacokinetic (PK) principles has created a synergistic partnership that plays a vital, influential role in the discovery and development of new medicines. In the bioanalytical investigation a fast, sensitive, accurate and reproducible high performance liquid chromatography-mass spectrometry method has been developed & validated for the quantitative estimation of DOXAZOSIN in human plasma using DOXAZOSIN D8 used as internal standard by solid phase extraction (SPE) technique.Doxazosin, is an oral drug used for treating high blood pressure and symptoms of benign prostatic hyperplasia, it belongs to the class of alpha -1 adrenergic blockers. It prevents Norepinephrine that is released by nerves from binding to alpha -1 receptors on smooth muscles surrounding blood vessels and in prostate and bladder by blocking the effect of norepinephrine, Doxazosin relaxes the smooth muscles, relaxation of smooth muscle surrounding blood vessels causes them to enlarge (dilate) and thereby reduces blood pressure.