Bioinformatics

Marek Kimmel

ISBN 10: 3642063322 / ISBN 13: 9783642063329

Edité par Springer Berlin Heidelberg, 2010

A propos de cet article

Druck auf Anfrage Neuware - Printed after ordering - Bioinformatics as a discipline arose out of the need to introduce order into the massive data sets produced by the new technologies of molecular biology: large-scale DNA sequencing, measurements of RNA concentrations in multiple gene expression arrays, and new profiling techniques in proteomics. As such, bioinformatics integrates a number of traditional quantitative sciences such as mathematics, statistics, computer science and cybernetics with biological sciences such as genetics, genomics, proteomics and molecular evolution. In this comprehensive textbook, Polanski and Kimmel present mathematical models in bioinformatics and they describe the biological problems that inspire the computer science tools used to handle the enormous data sets involved. The first part of the book covers the mathematical and computational methods, while the practical applications are presented in the second part. The mathematical presentation is descriptive and avoids unnecessary formalism, and yet remains clear and precise. Emphasis is laid on motivation through biological problems and cross applications. Each of the four chapters in the first part is accompanied by exercises and problems to support an understanding of the techniques presented. Each of the six chapters of the second part is devoted to some specific application domain: sequence alignment, molecular phylogenetics and coalescence theory, genomics, proteomics, RNA, and DNA microarrays. Each chapter concludes with a problems and projects section, to deepen the reader's understanding and to allow for the design of derived methods. Many of the projects involve publicly available software and/or Web-based bioinformatics depositories. Finally, the book closes with a thorough bibliography, reaching from classic research results to very recent findings, providing many pointers for future research.Overall, this volume is ideally suited for a senior undergraduate or graduate course on bioinformatics, with a strong focuson its mathematical and computer science background.

N° de réf. du vendeur 9783642063329

Détails bibliographiques

• Titre: Bioinformatics
• Éditeur: Springer Berlin Heidelberg
• Date de parution: 2010
• Langue: anglais
• ISBN à 10 chiffres: 3642063322
• ISBN à 13 chiffres: 9783642063329
• Reliure: Taschenbuch
• État de l'article: Neu
• Dimensions: 235 L x 155 H x 22 P (en millimètres) 235 millimètres de largeur par 155 millimètres de hauteur par 22 millimètres de profondeur
• Poids: 598 grammes

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Synopsis

Bioinformatics is a discipline born of the need to introduce order into massive datasets produced by new technologies of molecular biology: large-scale DNA sequencing, measurements of RNA concentrations in multiple gene expression arrays and new profiling techniques in proteomics. This volume presents mathematical models in bioinformatics along with descriptions of inspiring biological problems and computer science tools necessary to cope with data. The material covered includes widely used applications in genomics and proteomics and later-generation techniques, which attempts at linking genetic information with structure and function of molecules, metabolic processes and whole cells. Each chapter concludes with a problems and projects section, to deepen the reader's understanding and to allow for the design of derived methods. Many of the projects involve publicly available software and/or Web-based bioinformatics depositories.

À propos de l?auteur

Andrzej Polanski is Professor at the Silesian University of Technology. Prior to this, he worked as a Post Doctoral Fellow at the University of Texas, Human Genetics Center, Houston USA (1996-1997) ans as a Visiting Professor at Rice University, Houston USA (2001-2003). His research interests are in bioinformatics, biomedical modeling and control, modern control and optimization theory.

Marek Kimmel, Ph.D., is a Professor of Statistics at Rice University in Houston, TX, Professor in Department of Automatic Control, Silesian University of Technology in Gliwice, Poland, Professor of Biostatistics and Applied Mathematics (adj.) at M.D. Anderson Cancer Center in Houston, and a Professor of Biometry (adj.) at the School of Public Health of the University of Texas in Houston. He is heading the Rice Bioinformatics Group as well as the doctoral program in Statistical Genetics and Bioinformatics. Dr. Kimmel is a Fellow of the American Statistical Association. His principal interests are stochastic modeling of human disease (in particular lung cancer progression and screening), statistical and population genetics, biostatistics and bioinformatics.