Biotics and the Gut-Brain Axis in Neurological Disorders

This book reviews the pivotal role of prebiotics, probiotics, and postbiotics in modulating the gut–brain axis, offering insights into their potential therapeutic applications and impact on neurological health. The initial chapters provide a foundational overview of prebiotics and introduce readers to the concept of the gut–brain axis. These chapters discuss bidirectional communication within the gut–brain axis and the impacts of gut dysbiosis on neurological health. Further chapters investigate the relationship between the gut–brain axis and autoimmune diseases, as well as the role of probiotics in major neurodegenerative diseases such as Alzheimer’s and Parkinson’s, amyotrophic lateral sclerosis (ALS), Huntington’s disease, and conditions like multiple sclerosis (MS), epilepsy, and seizures. The book also examines the influence of prebiotics on mental health disorders such as anxiety and depression, and their impact on ischemic stroke via the gut–brain axis. It further covers the role of probiotics in reactive oxygen species (ROS) and inflammation-mediated neurodegenerative diseases and explores the correlation between gut microbiota, malnutrition, and neurological disorders. The book explores signaling pathways within the gut–brain axis and their relationships with neurological disorders, the application of prebiotics as functional foods, and the therapeutic potential of postbiotics and psychobiotics. This book is intended for scientists and researchers in the fields of microbiology, neuroscience, and gastroenterology. The book:

• Provides a thorough understanding of prebiotics, probiotics, and postbiotics, and their roles in the gut–brain axis
• Explores bidirectional communication within the gut–brain axis and its impact on neurological health
• Examines the relationship between the gut microbiota and various neurological disorders
• Discusses the influence of prebiotics and probiotics on mental health disorders such as anxiety and depression
• Investigates the connection between the gut–brain axis and autoimmune diseases
• Covers advanced tools and bioinformatics approaches for studying gut microbiota and neurodegeneration

Neeraj Mishra has been serving as Professor and Head of the Department at the Amity Institute of Pharmacy, Amity University, Gwalior, India, since July 2019. With approximately 20 years of experience in teaching and research, Dr. Mishra has made significant contributions to the field. He has over 125 publications in both international and national journals, focusing on novel drug delivery systems, oral delivery of synbiotics, localized drug delivery, and targeted and controlled delivery of nanocarriers and microparticles for treating breast and colon cancer, as well as neurodegenerative disorders. He has authored more than 15 books and 25 book chapters and holds three international patents and three Indian patents. His achievements have been recognized with several awards, including the “Distinguished Professor Award” from DST-NSTMIS, SPAICS, Indore, in 2019, and the “Outstanding Scientist Award” at the 6th International Scientist Awards on Engineering, Science, and Medicine in 2020. He also received the “Distinguished Professor Award” from the Indian Pharmaceutical Association, MP State Branch, in 2021, and the “Best Academician Award” at the Indian Pharmacy Graduate Association, M.P. State International Conference in 2023.

Sumel Ashique is Assistant Professor in the Department of Pharmaceutical Technology, Bharat Technology, Howrah, India. With five years of teaching experience, he has made notable contributions to his field. He has published more than 100 papers in reputable international and national journals. His expertise includes drug delivery, nanotechnology, and targeted treatment strategies. He also serves as a reviewer for several prestigious international journals. He holds five granted patents from IP Australia, India, and Canada. He has contributed to 20 book chapters and has edited 18 books.

Mithun Bhowmick is Professor and Principal at the Bengal College of Pharmaceutical Sciences & Research in Durgapur, West Bengal, India. He has received numerous prestigious awards throughout his career. Dr. Bhowmick has actively participated in and presented research papers at various international and national conferences. He has published more than 50 research and review papers in esteemed national and international journals. His accomplishments include several patents from Australia, Germany, and India, as well as design patents and copyrights. Dr. Bhowmick is a reviewer for numerous pharmaceutical journals and is a lifetime member of several professional organizations, including the Association of Pharmaceutical Teachers of India (APTI), the Indian Pharmacy Graduates’ Association (IPGA), and the Institute of Scholars (InSc.). He is also a registered fellow member of the Centre for Education Growth and Research (CEGR) in New Delhi.