Cancer Biology

Langue : anglais

Edité par W.F Sep 2026, 2026

8091989830 / 9788091989831

Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, AllemagneBuchWeltWeit Ludwig Meier e.K.

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This item is printed on demand - it takes 3-4 days longer - Neuware -Cancer is not simply uncontrolled cell growth. It is an evolving biological system in which genetic and epigenetic alterations reshape cellular behavior, disrupt tissue organization, alter interactions with the tumor microenvironment, and create populations capable of invasion, metastasis, persistence, and resistance to treatment.Cancer Biology presents cancer through this mechanistic framework, connecting molecular alterations to cellular behavior, tumor evolution, clinical phenotype, and therapeutic response.The book begins with the biological systems that normally regulate cellular growth, survival, differentiation, genomic integrity, and tissue organization. It then examines how these controls become disrupted through cancer genetics, oncogenes, tumor suppressor genes, DNA damage and repair defects, genomic instability, and epigenetic reprogramming.Particular attention is given to the evolutionary nature of cancer. Tumors are composed of genetically and phenotypically diverse populations that compete, adapt, and respond differently to changing conditions. Clonal evolution, tumor heterogeneity, cellular plasticity, cancer metabolism, replicative immortality, and treatment-driven selection are therefore considered as interconnected processes rather than isolated concepts.The biology of the tumor extends beyond the malignant cell. The tumor microenvironment, including cancer-associated fibroblasts, extracellular matrix, blood vessels, immune cells, inflammatory signals, oxygen availability, and metabolic conditions, can influence tumor growth, invasion, metastasis, immune evasion, and therapeutic response.The book also connects fundamental cancer biology with clinical practice, covering: - Cancer genetics, genomics, mutations, copy-number alterations, gene fusions, and driver alterations- Oncogenes and tumor suppressors, including TP53, RB, RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, and WNT/ß-catenin- DNA damage, DNA repair, replication stress, and genomic instability- Epigenetic regulation, chromatin remodeling, cellular identity, and plasticity- Clonal evolution, tumor heterogeneity, cancer-cell states, and tumor persistence- Cancer metabolism, hypoxia, angiogenesis, inflammation, and the tumor microenvironment- Immune surveillance, immune evasion, immunoediting, and tumor immunology- Invasion, metastasis, organ colonization, dormancy, residual disease, and recurrence- Pathology, molecular classification, biomarkers, liquid biopsy, staging, and early detection- Cancer treatment, including surgery, radiation, cytotoxic, targeted, endocrine, and immune-based therapies- Precision oncology, single-cell and spatial biology, functional genomics, artificial intelligence, and patient-derived modelsThe emphasis throughout is not merely on what changes in cancer, but on what those changes allow the cancer cell or tumor to do. 522 pp. Englisch.…

N° de réf. du vendeur 9788091989831

Détails bibliographiques

Titre
Cancer Biology
Auteur
Wiegand Falkner
Éditeur
W.F Sep 2026
Année de publication
2026
État de l'article
Neu
Reliure
Taschenbuch
Langue
anglais
ISBN à 10 chiffres
8091989830
ISBN à 13 chiffres
9788091989831
Poids de l'article
1 197 grammes
Dimensions
279x216x27 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Allemagne

Vendeur avec une évaluation de 5 étoiles

Vendeur AbeBooks depuis 11 janvier 2012

Frais d'expédition de Allemagne vers Etats-Unis

Article5 à 15 jours ouvrés5 à 15 jours ouvrés
Premier articleEUR 23,00EUR 23,00
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BuchWeltWeit Ludwig Meier e.K.

Allemagne