Chromatin and Disease

. Ed(s): Kundu, Tapas K.; Dasgupta, Dipak

ISBN 10: 1402054653 / ISBN 13: 9781402054655

Edité par Springer-Verlag New York Inc., 2007

A propos de cet article

Different processes such as chromatin assembly, remodeling of chromatin structure coupled to covalent modification of histone and non-histone proteins, chromatin modifying enzymes and DNA-templated phenomena are the potential drug targets for diseases. This work provides an overview of the research activities in these areas. Editor(s): Kundu, Tapas K.; Dasgupta, Dipak. Series: Subcellular Biochemistry. Num Pages: 472 pages, biography. BIC Classification: PSAK. Category: (P) Professional & Vocational; (UP) Postgraduate, Research & Scholarly. Dimension: 235 x 155 x 23. Weight in Grams: 951. . 2007. Hardback. . . . . Books ship from the US and Ireland.

N° de réf. du vendeur V9781402054655

Détails bibliographiques

• Titre: Chromatin and Disease
• Éditeur: Springer-Verlag New York Inc.
• Date de parution: 2007
• Langue: anglais
• ISBN à 10 chiffres: 1402054653
• ISBN à 13 chiffres: 9781402054655
• Reliure: Couverture rigide
• État de l'article: New

A propos de ce titre

Synopsis

It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, recombination and also apoptosis. The dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different chromatin interacting n- histone proteins. Dysfunction of this highly inter connected machineries disturb the cellular homoeostasis, and thereby causes several diseases. As we advance in our knowledge of chromatin function and also disease mechanisms in more details, their causal relationship is becoming more evident. This has lead to the identification of chromatin function as target for new generation therapeutics. In the light of these advances, it happens to be the right time to explore current insights into various aspect of chromatin and disease connection under one cover. Authors who are actively involved in chromatin research and have made several original contributions to develop latest paradigms in the field have written the chapters of this book. Significantly, the authors' repertoire is truly international. They come from eight different countries of Asia, Europe and America. The book has been divided into three different parts. Part I introduces the reader to the dynamic nature of chromatin structure and its link to diseases. First two chapters in this part deal with the chromatin architecture, chromatin dynamics in the cell cycle and molecular mechanism of chromatin remodeling.