The purpose of this primer is to provide students, teachers as well as academic and industry researchers with a succinct account of the chemical and structural features of chromatin and the role that these features play in the maintenance and function of the genetic material. It is universally accepted that DNA is the carrier of the genetic information that is transmitted from parents to their offspring and that it is responsible for the anatomy, physiology and behavior of all individuals throughout development and adult life. Yet, how this information is retrieved and used selectively to allow a fertilized egg to become an organism made up of myriads of different cells and tissues is not as evident and easily understood. Dr Lucchesi, an internationally known researcher and teacher, provides an easily opened window into the role that the complex of proteins and nucleic acids that are associated with the DNA play in mediating gene expression and in responding to environmental circumstances.

� propos de l?auteur

John Lucchesi obtained a PhD in Genetics from the University of California at Berkeley in 1963. Following two years of postdoctoral training in the Institute of Molecular Biology at the University of Oregon, he joined the faculty of the University of North Carolina in Chapel Hill, where he rose to the rank of Cary C Boshamer Professor of Biology and Genetics. In 1979 he was appointed Adjunct Professor of Genetics, Duke University; in 1983, he was named Senior Fellow of Churchill College, Cambridge University, UK. In 1990, he joined the faculty of the Biology Department at Emory University as Asa G. Candler Professor of Biology and Chair. Dr Lucchesi has served on numerous National Institutes of Health panels including chairing the Genetics Study Section of the Division of Research Grants. He is a Fellow of the AAAS, a former President of the Genetics Society of America and was named Vice-President of the XVII International Congress of Genetics. His research laboratory, continuously supported by funding from the National Institute of General Medical Sciences, has focused on the regulation of transcription, the functional architecture of chromatin and the genetic regulation of development.

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