Chromatographic Enantioseparation of Pharamaceutical Compounds : High Performance Liquid Chromatography and Thin Layer Chromatography

Sonika Batra

ISBN 10: 3639662857 / ISBN 13: 9783639662856

Edité par Scholars' Press, 2014

A propos de cet article

nach der Bestellung gedruckt Neuware - Printed after ordering - Chirality is a fundamental characteristic of all living organisms, and all essential biochemical processes exhibit enantioselectivity. Although enantiomers of one compound do not possess any physical differences, they show difference in physiological and chemical activity in biological systems. In general, one enantiomer of most of the racemic drugs shows significantly higher pharmacological activity than the other. In some cases one enantiomer can be totally inactive or in others, it can produce adverse side effects. Therefore, preparation and analysis of single enantiomer becomes important. This book deals with studies on direct and indirect enantioseparation of certain pharmaceutical compounds which are marketed as their racemic mixtures. These chiral compounds/ drugs are (RS)-Bupropion (Bup), (RS)-Baclofen (Bac), (RS)-Mexiletine (Mex) and (RS)-Fluoxetine (Flx). The enantiomeric separation carried out using different Chiral Derivatizing Reagents (CDRs), Chiral Stationary Phases (CSPs) and chiral selectors by means of Reversed Phase (RP)-HPLC, impregnated TLC or Chiral Ligand Exchange TLC has been discussed.

N° de réf. du vendeur 9783639662856

Détails bibliographiques

• Titre: Chromatographic Enantioseparation of Pharamaceutical Compounds : High Performance Liquid Chromatography and Thin Layer Chromatography
• Éditeur: Scholars' Press
• Date de parution: 2014
• Langue: anglais
• ISBN à 10 chiffres: 3639662857
• ISBN à 13 chiffres: 9783639662856
• Reliure: Taschenbuch
• État de l'article: Neu

A propos de ce titre

Synopsis

Chirality is a fundamental characteristic of all living organisms, and all essential biochemical processes exhibit enantioselectivity. Although enantiomers of one compound do not possess any physical differences, they show difference in physiological and chemical activity in biological systems. In general, one enantiomer of most of the racemic drugs shows significantly higher pharmacological activity than the other. In some cases one enantiomer can be totally inactive or in others, it can produce adverse side effects. Therefore, preparation and analysis of single enantiomer becomes important. This book deals with studies on direct and indirect enantioseparation of certain pharmaceutical compounds which are marketed as their racemic mixtures. These chiral compounds/ drugs are (RS)-Bupropion (Bup), (RS)-Baclofen (Bac), (RS)-Mexiletine (Mex) and (RS)-Fluoxetine (Flx). The enantiomeric separation carried out using different Chiral Derivatizing Reagents (CDRs), Chiral Stationary Phases (CSPs) and chiral selectors by means of Reversed Phase (RP)-HPLC, impregnated TLC or Chiral Ligand Exchange TLC has been discussed.