Combinatorial Chemistry Synthesis and Application

Wilson, Stephen R. (Editor)/ Czarnik, Anthony W. (Editor)

ISBN 10: 047112687X / ISBN 13: 9780471126874

Edité par Wiley-Interscience, 1997

A propos de cet article

1st edition. 288 pages. 9.50x6.50x0.50 inches. In Stock. N° de réf. du vendeur x-047112687X

Détails bibliographiques

Titre : Combinatorial Chemistry Synthesis and ...

Éditeur : Wiley-Interscience

Date d'édition : 1997

Reliure : Hardcover

Etat : Brand New

A propos de ce titre

Synopsis :

viii 269p blue laminated boards, bookplate, as new

Présentation de l'éditeur:

The new time–saving revolution in drug discovery.

Combinatorial chemistry, a method for synthesizing millions of chemical compounds much faster than usual, is becoming one of the most useful technical tools available to chemists and researchers working today. Using current advances in computer and laboratory techniques, combinatorial chemistry has freed professionals from the drudgery of piecemeal experimental work and opened new creative possibilities for experimentation.

Combinatorial Chemistry: Synthesis and Application details critical aspects of the technique, featuring the work of some of the world′s leading chemists, many of whom played a key role in its development. Including examples of both solution–phase and solid–phase approaches as well as the full complement of organic chemistry technologies currently available, the book describes:
∗ Concepts and terms of combinatorial chemistry
∗ Polymer–supported synthesis of organic compounds
∗ Macro beads as microreactors
∗ Solid–phase methods in combinatorial chemistry
∗ Encoded combinatorial libraries, including Rf–encoding of synthesis beads
∗ Strategies for combinatorial libraries of oligosaccharides
∗ Combinatorial libraries of peptides, proteins, and antibodies using biological systems.

While combinatorial chemistry originated in peptide chemistry, this volume has deliberately focused on nonpeptide organic applications, illustrating the technique′s wide uses. Combinatorial Chemistry introduces organic, medicinal, and pharmaceutical chemists as well as biochemists to this exciting, cost–effective, and practical technique, which has unlocked creative potential for the next millennium.