Comparative And Veterinary Pharmacology. Cet article n’est pas disponible.Comparative And Veterinary Pharmacology

The human-animal bond has evolved and diversi?ed down the ages. Dogs, cats and even horses, have long ful?lled the role of faithful companion and indeed, as exempli?ed by the introduction of seeing and hearing dogs, there may be a critical level of co-dependency between the species. In the twenty-?rst century, the animal types that are kept as pets in many parts of the world are extensive ranging from reptiles through rodents to ruminants and beyond. As would be predicted by the nature of the relationship, the approach to treatment of a companion animal is often closely aligned to that which would have been offered to their owner. However, an increasing awareness of welfare issues, such as the recognition that animals expe- ence pain and the proven bene?ts of disease prevention in intensive farming units, together with the growth in zoos and wildlife parks, has increased the likelihood of food producing and non-domesticated animals receiving medicinal products during their life-time. Although many of the individual drugs or classes of drugs administered to animals are the same as, or derived from, those given to man, the safe and effective use of drugs in animals often cannot be achieved by simply transposing knowledge of drug action on, or behaviour in, the body from one species to another. The impact of the anatomical, physiological and pathophysiological variability that spans the animal kingdom can often profoundly alter drug response.

The topics addressed in this volume of comparative and veterinary pharmacology, as a series of succinct state of the art reviews, illustrate both the commonality and differences between drug pharmacodynamics and pharmacokinetics in animals and man and demonstrate the potential impact of drug use in animals on human health and the environment. Genetic modification of animals and the benefits this has brought to understanding human disease and the production of drugs for use in man is considered and the potential of new technologies for improving the treatment of animal disease explored.