Coumarin for Cancer Treatment

Coumarin, a naturally occurring benzo-α-pyrone compound that is most often used as a fragrance ingredient, is also beneficial in the treatment of prostate cancer, renal cell carcinoma, leukemia, and other cancers. This new volume provides an in-depth discussion of the various applications of coumarin compounds in cancer treatment, exploring the most recent developments, extraction processes, and tailored approaches to use coumarins for cancer treatment. It presents a complete overview of the distinct uses of coumarin compounds in cancer treatment as well as insights into their various modes of action and therapeutic efficacy. The book also addresses coumarin potential as an enzyme inhibitor for cancer management, the therapeutic potential of natural coumarin lead compounds, and the use of coumarin derivatives as radiosensitizers in cancer treatment.

Coumarins for Cancer Treatment: Advances and Prospects, authored by prominent experts, covers potential strategies and recent breakthroughs in utilizing coumarins for cancer treatment, extraction techniques, prodrug design approaches for tumor targeting, nanoformulations for tumor targeting, gastrointestinal cancers, herniarin and psoralen for cancer treatment, warfarin anticancer effect, target-based coumarin derivatives as effective anticancer agents, the photoprotective and anti-melanoma activity of coumarin phytoestrogen, coumestrol, curcumin role in epithelial-mesenchymal transition for preventing cellular metastasis, utilization of coumarin and its derivatives against breast cancer, the potential of coumarin as an enzyme inhibitor for cancer management, natural coumarin lead compounds, and coumarin derivatives as radiosensitizers in cancer treatment.

The book also explores clinical research, regulatory prospects, and patents associated with coumarin-based cancer treatment techniques, providing a complete overview of the translational and commercial elements of coumarin-based cancer medicines.

The book will be a great resource for academicians, physicians, biotechnologists, and pharmaceutical professionals working on the development and implementation of new cancer therapy modalities that use coumarin molecules.

Rishabha Malviya, PhD, has 13 years of research experience and has been working as an Associate Professor in the Department of Pharmacy, School of Medical and Allied Sciences at Galgotias University, India, for the past 11 years. His area of interest includes formulation optimization, nanoformulation, targeted drug delivery, localized drug delivery, and characterization of natural polymers as pharmaceutical excipients. He has authored more than 150 research and review papers for national/international journals of repute. He has over 50 patents (12 grants, 38 published, one filed). He has received an outstanding reviewer award from Elsevier. He has authored and/or edited 70 books (Wiley, Springer Nature, De Gruyter, CRC Press/Taylor and Francis, River Publisher, Apple Academic Press, Nova Science Publishers, and OMICS International) and authored 125 book chapters. His name has been included in the world top 2% scientists list for the years 2020, 2021, and 2022 by Elsevier BV and Stanford University. He is a reviewer, editor, and editorial board member of more than 50 national and international journals of repute. He completed a BPharm at Uttar Pradesh Technical University and an MPharm (Pharmaceutics) at Gautam Buddha Technical University, Lucknow Uttar Pradesh, India. His PhD (Pharmacy) work was in novel formulation development techniques.

Kamla Pathak, PhD, is Dean and Professor in the Faculty of Pharmacy at Uttar Pradesh University of Medical Sciences, Etawah, India. With teaching and research experience of more than 30 years, she is actively engaged in research on oral controlled, modulated, and targeted and topical drug delivery systems, and has received many awards for her work. She has over 270 publications in journals of international and national repute. She also holds three patents and has authored four books and more than 20 book chapters. She has also written many abstracts in various scientific forums and has been a reviewer for national and international journals in pharmaceutics. Professor Pathak has served as a member of the editorial advisory board of AAPS Pharm Sci Tech and is also a member of various professional bodies. She has guided more than 120 PhD and postgraduate students. She is also associated with the Indian pharmaceutical industry in the capacity of scientific consultant. She is credited as reviewer of several scientific projects including Knowledge Foundation, Sweden, and Israel Science Foundation. She has participated at national and international seminars and conferences as organizer, invited speaker, and chairperson of scientific sessions. She has been listed in the top 2% Indian scientists in the subsection pharmacology and pharmacy in the World Top 2% Scientists list released by Stanford University in 2020 and 2021. She graduated (Pharmaceutics) from the University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India, where she earned her doctorate in Pharmacy.

Sudhanshu Mishra, MPharm, is currently affiliated with the Department of Pharmaceutical Science & Technology, Madan Mohan Malaviya University of Technology, Gorakhpur, India. His areas of interest include novel formulations, nano-herbal formulation, transdermal drug delivery, localized drug delivery, etc. He has authored over 50 research and review articles for national and international journals. He is also working on different novel approaches and technology for targeting chronic diseases. He is a reviewer and also an editorial board member of national and international journals. He has also participated in academic activities such as international seminars, conferences, workshops, and oral presentations. He completed his MPharm (Pharmaceutics) at the School of Pharmaceutical Science, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal and is pursuing his PhD at Dr APJ Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India.

Sonali Sundram, MPharm, is Assistant Professor in the School of Medical & Allied Sciences at Galgotias University, Greater Noida, Uttar Pradesh, India. She previously worked as research scientist on a project of Indian Council of Medical Research (ICMR) at King George Medical University, Lucknow, India. After that, she joined BBDNIIT (Babu Banarasi Das Northern India Institute of Technology), Lucknow. Her PhD (Pharmacy) work was in the area of neurodegeneration and nanoformulation. Her areas of interest are neurodegeneration, clinical research, and artificial intelligence. She has authored and edited more than 15 books (Wiley, CRC Press/Taylor and Francis, IOP Publishing, Apple Academic Press, Springer Nature, and River Publisher). She has attended and organized more than 15 national and international seminar, conferences, and workshops. She has more than eight patents national and international to her credit. She has published six SCI-indexed manuscripts with reputed international publishers and has delivered oral presentations at international conferences. She completed both BPharm and MPharm (Pharmacology) at Dr. A.P.J. Abdul Kalam Technical University, Lucknow, India.