D-Dopachrome Tautomerase (D-DT) : Functional Homologue or Cross-Regulator of Macrophage Migration Inhibitory Factor (MIF)?

Wibke Karin Schulte

ISBN 10: 3838131614 / ISBN 13: 9783838131610

Edité par Südwestdeutscher Verlag Für Hochschulschriften, 2012

A propos de cet article

nach der Bestellung gedruckt Neuware - Printed after ordering - Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and a pivotal regulator of the immune response implicated in the pathogenesis of various acute and chronic inflammatory diseases. In 1993, D-dopachrome tautomerase (D-DT) was discovered during an investigation of melanogenesis. The tertiary structure of D-DT is remarkably similar to MIF, identifying D-DT as the only known eukaryotic MIF homologue discovered to date. Despite D-DT's intriguing similarities to the very well studied MIF, there have been very few reports on the biological functions and mechanisms of action of D-DT. This dissertation aimed at the functional characterization of D-DT in biological and pathophysiologic conditions.

N° de réf. du vendeur 9783838131610

Détails bibliographiques

• Titre: D-Dopachrome Tautomerase (D-DT) : Functional Homologue or Cross-Regulator of Macrophage Migration Inhibitory Factor (MIF)?
• Éditeur: Südwestdeutscher Verlag Für Hochschulschriften
• Date de parution: 2012
• Langue: anglais
• ISBN à 10 chiffres: 3838131614
• ISBN à 13 chiffres: 9783838131610
• Reliure: Taschenbuch
• État de l'article: Neu
• Dimensions: 220 L x 150 H x 6 P (en millimètres) 220 millimètres de largeur par 150 millimètres de hauteur par 6 millimètres de profondeur
• Poids: 167 grammes

A propos de ce titre

Synopsis

Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and a pivotal regulator of the immune response implicated in the pathogenesis of various acute and chronic inflammatory diseases. In 1993, D-dopachrome tautomerase (D-DT) was discovered during an investigation of melanogenesis. The tertiary structure of D-DT is remarkably similar to MIF, identifying D-DT as the only known eukaryotic MIF homologue discovered to date. Despite D-DT’s intriguing similarities to the very well studied MIF, there have been very few reports on the biological functions and mechanisms of action of D-DT. This dissertation aimed at the functional characterization of D-DT in biological and pathophysiologic conditions.

À propos de l?auteur

Was born in 1986 in Lüdinghausen, Germany. She studied medicine at RWTH Aachen University and received her M.D. degree in 2011. Her dissertation was conducted at RWTH Aachen University and Yale University School of Medicine, USA.