Design and Optimization in Organic Synthesis (Data Handling in Science and Technology, Volume 8)

Carlson, R.

ISBN 10: 044489201X / ISBN 13: 9780444892010

Edité par Elsevier Science Ltd, 2000

4th impression. Light wear to boards with a lean. Content is clean and bright with light marks on the outer edge pages. No DJ. N° de réf. du vendeur 9999-9994054144

Synopsis :

This is the first general textbook on experimental design and optimization in organic synthesis. The book presents a unified methodology for carrying out systematic studies when the objective is to develop efficient and optimum synthetic methods. Strategies are included both for exploring the experimental conditions and for systematic studies of entire reaction systems (substrates, reagent(s) and solvents). The methodology is based on multivariate statistical techniques. The following topics are treated in depth: classical two-level designs for screening experiments, gradient methods (steepest ascent, simplex methods) as well as response surface techniques for optimization, principal components analysis and PLS modelling.The book is intended as a hands-on text for chemists and engineers engaged in developing synthetic methods in industrial research, e.g. in fine chemicals and pharmaceuticals production, as well as for advanced undergraduate students, graduate students, and researchers in an academic environment.

Présentation de l'éditeur: Revised, and updated Design and Optimization in Organic Synthesis presents strategies to explore experimental conditions and methodologies for systematic studies of entire reaction systems (substrates, reagent(s), catalyst(s), and solvents). Chemical phenomena are not usually the result of a single factor and this book describes how statistically designed methods can be used to analyse and evaluate synthetic procedures. The methodology is based on multivariate statistical techniques. The accompanying CD contains data tables and programmes. This book is essential reading for anyone working in process design and development in fine chemicals or the pharmaceutical industry, and is suitable for those with no experience in the field.

* Contains recalculated models and redrawn figures, as well as new chapters on for example, the design of combinatorial libraries
* Presents strategies to explore experimental conditions and methodologies
* Enables the analysis and prediction of the best synthetic procedures

Détails bibliographiques

Titre : Design and Optimization in Organic Synthesis...
Éditeur : Elsevier Science Ltd
Date d'édition : 2000
Reliure : Couverture rigide
Etat : Good
Edition : 3ème Édition