Discoidin Domain Receptors in Health and Disease

Langue : anglais

Edité par Springer, Springer US Jun 2018, 2018

149398182X / 9781493981823

Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagnebuchversandmimpf2000

Vendeur avec une évaluation de 5 étoiles

Vendeur AbeBooks depuis 23 janvier 2017

Afficher les articles de ce vendeur
Livre broché

Etat: Neuf

EUR 160,49

EUR 60,00 expédition 
Expédition depuis Allemagne vers Etats-Unis

Quantité disponible : 1 disponible(s)

Ajouter au panier

Item description from seller

This item is printed on demand - Print on Demand Titel. Neuware -The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK functionand disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 372 pp. Englisch.

N° de réf. du vendeur 9781493981823

Titre
Discoidin Domain Receptors in Health and Disease
Auteur
Rafael Fridman
Éditeur
Springer, Springer US Jun 2018
Année de publication
2018
État de l'article
Neu
Reliure
Taschenbuch
Langue
anglais
ISBN à 10 chiffres
149398182X
ISBN à 13 chiffres
9781493981823
Poids de l'article
563 grammes
Dimensions
235x155x21 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Allemagne

Vendeur avec une évaluation de 5 étoiles

Vendeur AbeBooks depuis 23 janvier 2017

Frais d'expédition de Allemagne vers Etats-Unis

Article60 à 60 jours ouvrés60 à 60 jours ouvrés
Premier articleEUR 60,00EUR 75,00
Les délais de livraison sont fixés par les vendeurs et varient en fonction du transporteur et du lieu. Les commandes transitant par les douanes peuvent être retardées et les acheteurs sont responsables de tous les droits ou frais associés. Les vendeurs peuvent vous contacter au sujet de frais supplémentaires afin de couvrir toute augmentation des coûts d'expédition de vos articles.

Modes de paiement

  • Visa
  • Mastercard
  • American Express
  • Carte Bleue
  • Apple Pay
  • Google Pay
  • Chèque
  • Paypal

Description de la boutique

Impressum Thorsten Retsch Buchversand Mimpf2000 Oberölschnitz 16 95517 Emtmannsberg Deutschland Telefon: 09209-2023188 Email: mimpf2000@online.de USt-ID-Nr.: DE 235096871 Wir führen gebrauchte Bücher aus allen Sparten der Literatur

Spécialité

Modernes Antiquariat - Bücher von 1960 bis heute

Profil professionnel du vendeur

buchversandmimpf2000

Allemagne