Effect of CoCl2 in vascular dysfunction of diabetic nephropathy

Deshmukh, Aaishwarya/ Patel, Jayvadan

ISBN 10: 6139927986 / ISBN 13: 9786139927982

Edité par LAP LAMBERT Academic Publishing, 2018

A propos de cet article

252 pages. 8.66x5.91x0.57 inches. In Stock.

N° de réf. du vendeur zk6139927986

Détails bibliographiques

• Titre: Effect of CoCl2 in vascular dysfunction of diabetic nephropathy
• Éditeur: LAP LAMBERT Academic Publishing
• Date de parution: 2018
• Langue: anglais
• ISBN à 10 chiffres: 6139927986
• ISBN à 13 chiffres: 9786139927982
• Reliure: Paperback
• État de l'article: Brand New
• Poids: 0,42 kilogramme

A propos de ce titre

Synopsis

A variety of human disorders are characterized by, or associated with, tissue hypoxia and manipulation of the HIF pathway has been predicted to significantly alter their clinical course. Early hopes of developing revolutionary PHD-based therapies have yet to translate into novel licensed pharmaceutical agents. Diabetic nephropathy, a progressive development of renal insufficiency in the setting of hyperglycaemia is the major single cause of chronic renal failure (CRF) in which hypoxia plays a critical role. The study investigated the efficacy of cobalt chloride (CoCl2), a Prolyl 4-hydroxylase (PHD) inhibitor in amelioration of renal injury, endothelial dysfunction as well as its effect on hyperglycemia in uninephrectomized diabetic rat. The study signifies the effect of CoCl2 in amelioration of renal failure and associated vascular dysfunctuion.