Effect Of Formulation Variables On Diclofenac Sodium Matrices: Use Of Natural Polymers In Sustained Drug Delivery Systems

Prasanna Jakka, Lakshmi; Nadendla, Rama Rao; Prasanthi N, Lakshmi; Prasanna Jakka, Lakshmi; Nadendla, Rama Rao; Prasanthi N, Lakshmi

ISBN 10: 3659273139 / ISBN 13: 9783659273131

Edité par Lap Lambert Academic Publishing, 2012

64 pages. 8.66x5.91x0.15 inches. In Stock. N° de réf. du vendeur 3659273139

Synopsis :

Over the past few years, interest in developing plant derived materials as formulation excipients has increased because of need in safe and novel excipients. Plant based materials such as gums and mucilages are gaining popularity in novel drug delivery systems due to their varying properties. The present study aims at developing matrix systems of diclofenac sodium using various gums. Release rate from the matrix systems is affected by various formulation variables. Formulation variables such as gum and its concentration, type of diluent used were investigated in this study. The study was conducted in two phases. Phase I: Formulation of matrix systems using different gums at different concentrations. Phase II: Formulation of matrix systems using different diluents with the best concentration of each gum when compared to a marketed product. Statistical evaluation of these processes was done to determine statistical significance. Thus the research work was successful in developing matrix tablets with desired effects using natural gums

Présentation de l'éditeur: Over the past few years, interest in developing plant derived materials as formulation excipients has increased because of need in safe and novel excipients. Plant based materials such as gums and mucilages are gaining popularity in novel drug delivery systems due to their varying properties. The present study aims at developing matrix systems of diclofenac sodium using various gums. Release rate from the matrix systems is affected by various formulation variables. Formulation variables such as gum and its concentration, type of diluent used were investigated in this study. The study was conducted in two phases. Phase I: Formulation of matrix systems using different gums at different concentrations. Phase II: Formulation of matrix systems using different diluents with the best concentration of each gum when compared to a marketed product. Statistical evaluation of these processes was done to determine statistical significance. Thus the research work was successful in developing matrix tablets with desired effects using natural gums

Détails bibliographiques

Titre : Effect Of Formulation Variables On ...
Éditeur : Lap Lambert Academic Publishing
Date d'édition : 2012
Reliure : Paperback
Etat : Brand New