Epigenetics and Disease

En Li

ISBN 10: 3034803052 / ISBN 13: 9783034803052

Edité par Springer Basel, Birkhäuser Mär 2012, 2012

A propos de cet article

This item is printed on demand - it takes 3-4 days longer - Neuware -Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders.Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML.This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications. 280 pp. Englisch.

N° de réf. du vendeur 9783034803052

Détails bibliographiques

• Titre: Epigenetics and Disease
• Éditeur: Springer Basel, Birkhäuser Mär 2012
• Date de parution: 2012
• Langue: anglais
• ISBN à 10 chiffres: 3034803052
• ISBN à 13 chiffres: 9783034803052
• Reliure: Taschenbuch
• État de l'article: Neu
• Dimensions: 235 L x 155 H x 16 P (en millimètres) 235 millimètres de largeur par 155 millimètres de hauteur par 16 millimètres de profondeur
• Poids: 429 grammes

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Synopsis

Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.