The Fluoroquinolone Connection

Miklos Fuzi

ISBN 10: 3330063696 / ISBN 13: 9783330063693

Edité par LAP LAMBERT Academic Publishing Mär 2017, 2017

A propos de cet article

Neuware -Author falling back on findings published by his group and reviewing data reported by other scientists shows how the extensive use of fluoroquinolones influenced the evolution of various multiresistant pathogens on a global scale. It is demonstrated that most bacteria will suffer enormous fitness costs when developing high-level resistance to fluoroquinolones. However, a few 'skillful' groups of pathogens proved capable of evolving favorable mutations conferring high-level resistance to fluoroquinolones with the concomitant preservation of vitality. As these multiresistant 'superbugs' have replaced other pathogens in many facilities they also contributed to the deterioration of the general antibiotic resistance status. Though further epidemiological studies are needed the available data strongly suggest that the judicious use of fluoroquinolones could be based on the constant monitoring of the clonal division of local pathogens: if the proportion of 'superbugs' is high a reduction in the use of fluoroquinolones should ameliorate the situation, however, when their proportion remains/becomes low the use of fluoroquinolones should be highly beneficial.Books on Demand GmbH, Überseering 33, 22297 Hamburg 52 pp. Englisch.

N° de réf. du vendeur 9783330063693

Détails bibliographiques

• Titre: The Fluoroquinolone Connection
• Éditeur: LAP LAMBERT Academic Publishing Mär 2017
• Date de parution: 2017
• Langue: anglais
• ISBN à 10 chiffres: 3330063696
• ISBN à 13 chiffres: 9783330063693
• Reliure: Taschenbuch
• État de l'article: Neu
• Dimensions: 220 L x 150 H x 4 P (en millimètres) 220 millimètres de largeur par 150 millimètres de hauteur par 4 millimètres de profondeur
• Poids: 96 grammes

A propos de ce titre

Synopsis

Author falling back on findings published by his group and reviewing data reported by other scientists shows how the extensive use of fluoroquinolones influenced the evolution of various multiresistant pathogens on a global scale. It is demonstrated that most bacteria will suffer enormous fitness costs when developing high-level resistance to fluoroquinolones. However, a few "skillful" groups of pathogens proved capable of evolving favorable mutations conferring high-level resistance to fluoroquinolones with the concomitant preservation of vitality. As these multiresistant "superbugs" have replaced other pathogens in many facilities they also contributed to the deterioration of the general antibiotic resistance status. Though further epidemiological studies are needed the available data strongly suggest that the judicious use of fluoroquinolones could be based on the constant monitoring of the clonal division of local pathogens: if the proportion of "superbugs" is high a reduction in the use of fluoroquinolones should ameliorate the situation, however, when their proportion remains/becomes low the use of fluoroquinolones should be highly beneficial.