Genomics and Proteomics: Principles, Technologies, and Applications

The book provides scope and knowledge on advanced techniques and its applications into the modern fields of biotechnology—genomics and proteomics. In this book, different genomics and proteomics technologies and principles are examined. The fundamental knowledge presented in this book opens up an entirely new way of approaching DNA chip technology, DNA array assembly, gene expression analysis, assessing changes in genomic DNA, structure-based functional genomics, protein networks, and so on.

Topics in the book include:

• Different gene products with a similar role in neuronal defense against oxidative

• Gene-gene and gene-environment interactions in genetic epidemiology

• Elucidation of proto-oncogene c-abl function with the use of mouse models and the disease model of chronic myeloid leukemia

• Next-generation sequencing, microbiome evaluation, molecular microbiology, and their impact on human health

• Proteomics and prostate cancer

• RNA interference therapeutics

• Molecular mechanisms of hepatitis C virus entry

• Molecular phylogenetics for elucidation of evolutionary processes from biological data

• The impact of transgenic crops on soil quality, microbial diversity, and plant-associated communities.

• Biotechnological and genomic approaches for abiotic stress tolerance in crop plants

The book will be valuable for biotechnology researchers and bioinformatics professionals and students in all fields of biotechnology and will serve to broaden their knowledge about these newer tools, techniques, innovations, and applications.

Devarajan Thangadurai, PhD, is senior assistant professor at Karnatak University in South India, president of theSociety for Applied Biotechnology, and general secretary for the Association for the Advancement of Biodiversity Science. In addition, Dr. Thangadurai is editor-in-chief of several journals, including Biotechnology, Bioinformatics and Bioengineering; Acta Biologica Indica; Biodiversity Research International; and the Asian Journal of Microbiology. He received his PhD in botany from Sri Krishnadevaraya University in South India. During 2002-2004, he worked as CSIR Senior Research Fellow with funding from the Ministry of Science and Technology, Government of India. He served as Postdoctoral Fellow at the University of Madeira, Portugal; University of Delhi, India; and ICAR National Research Centre for Banana, India. He is the recipient of the Best Young Scientist Award with a Gold Medal from Acharya Nagarjuna University and the VGST-SMYSR Young Scientist Award of the Government of Karnataka, Republic of India. He has edited/authored 15 books including Genetic Resources and Biotechnology (3 vols.); Genes, Genomes and Genomics (2 vols.); and Mycorrhizal Biotechnology with publishers of national and international reputation.

Jeyabalan Sangeetha, PhD, is the UGC Kothari Postdoctoral Fellow at Karnatak University in South India. She earned her a BSc in microbiology and PhD in environmental sciences from Bharathidasan University, Tiruchirappalli, Tamil Nadu, India. She holds also an MSc in environmental sciences from Bharathiar University, Coimbatore, Tamil Nadu, India. She is the recipient of the Tamil Nadu Government Scholarship and the Rajiv Gandhi National Fellowship of University Grants Commission, Government of India, for her doctoral studies. She has published approximately 20 manuscripts detailing the effect of pollutants on the environment, and has organized conferences, seminars, workshops, and lectures. Her main research interests are in the areas of environmental microbiology and environmental biotechnology, with particular emphasis on solid waste management, environmental impact assessment, and microbial degradation of hydrocarbons. Her scientific and community leadership have included serving as an editor of the journal Biodiversity Research International and secretary for the Society for Applied Biotechnology.