Group Sequential and Confirmatory Adaptive Designs in Clinical Trials (Springer Series in Pharmaceutical Statistics)
Langue : anglais
Edité par Springer-Verlag Publishing, 2016
Série : Livre 1 sur 6 - Springer Series in Pharmaceutical Statistics
- Livre relié
- Occasion
Vendeur : Salish Sea Books, Bellingham, WA, Etats-UnisSalish Sea Books
Vendeur AbeBooks depuis 15 mai 2007
Etat: Occasion - Assez bon
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Ajouter au panierA propos de cet article
Very Good; Hardcover; Light wear to the covers; Unblemished textblock edges; Name to the last endpaper, otherwise the endpapers and all text pages are clean and unmarked; The binding is excellent with a straight spine; This book will be shipped in a sturdy cardboard box with foam padding; Medium Format (8.5" - 9.75" tall); Blue and tan covers with title in white lettering; 2016, Springer-Verlag Publishing; 317 pages; "Group Sequential and Confirmatory Adaptive Designs in Clinical Trials (Springer Series in Pharmaceutical Statistics)," by Gernot Wassmer & Werner Brannath.
N° de réf. du vendeur SKU-040AK04905011
- Titre
- Group Sequential and Confirmatory Adaptive Designs in Clinical Trials (Springer Series in Pharmaceutical Statistics)
- Auteur
- Gernot Wassmer & Werner Brannath
- Éditeur
- Springer-Verlag Publishing
- Année de publication
- 2016
- État de l'article
- Very Good
- Reliure
- Couverture rigide
- Langue
- anglais
- ISBN à 10 chiffres
- 3319325604
- ISBN à 13 chiffres
- 9783319325606
- Série
- Livre 1 sur 6: Springer Series in Pharmaceutical Statistics
This book provides an up-to-date review of the general principles of and techniques for confirmatory adaptive designs. Confirmatory adaptive designs are a generalization of group sequential designs. With these designs, interim analyses are performed in order to stop the trial prematurely under control of the Type I error rate. In adaptive designs, it is also permissible to perform a data-driven change of relevant aspects of the study design at interim stages. This includes, for example, a sample-size reassessment, a treatment-arm selection or a selection of a pre-specified sub-population.
Essentially, this adaptive methodology was introduced in the 1990s. Since then, it has become popular and the object of intense discussion and still represents a rapidly growing field of statistical research. This book describes adaptive design methodology at an elementary level, while also considering designing and planning issues as well as methods for analyzing an adaptively planned trial. This includes estimation methods and methods for the determination of an overall p-value. Part I of the book provides the group sequential methods that are necessary for understanding and applying the adaptive design methodology supplied in Parts II and III of the book. The book contains many examples that illustrate use of the methods for practical application.
The book is primarily written for applied statisticians from academia and industry who are interested in confirmatory adaptive designs. It is assumed that readers are familiar with the basic principles of descriptive statistics, parameter estimation and statistical testing. This book will also be suitable for an advanced statistical course for applied statisticians or clinicians with a sound statistical background.
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À propos de l’auteur
Gernot Wassmer is an Adjunct Professor of Biostatistics at the Institute of Medical Statistics, University of Cologne, Germany. He received his PhD from the University of Munich, Germany in 1993, after which he was a Research Fellow at Munich's Institute of Medical Statistics, at the Institute for Epidemiology, GSF Neuherberg, and at the Institute of Medical Statistics, University of Cologne. His major research interest is in the field of statistical procedures for group sequential and adaptive plans in clinical trials. He has been a member of independent data monitoring committees for international, multi-center trials in various therapeutic fields and also serves as a consultant for the pharmaceutical industry.
Werner Brannath is a Professor of Biostatistics at the Faculty of Mathematics and Informatics, University of Bremen, where he is also head of the biometry group at the Competence Center for Clinical Trials. He has extensiveexperience in the planning and analysis of clinical trials and has been a member of several independent data monitoring committees. His main research interests include adaptive and group sequential designs, as well as multiple testing.
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Salish Sea Books
Bellingham, WA, Etats-Unis
Vendeur AbeBooks depuis 15 mai 2007
Frais d'expédition à l'intérieur de ce pays : Etats-Unis
| Article | 5 à 14 jours ouvrés | 1 à 3 jours ouvrés |
|---|---|---|
| Premier article | EUR 4,48 | EUR 11,64 |
Modes de paiement
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Thank you for taking an interest in one of our books. Please see the "Shipping Terms" section below for details on our shipping and returns policies. We are a mail-order only bookstore located in Bellingham, WA specializing in modern out-of-print books of all genres. If you are an international customer, we ship internationally by UPS Worldwide Expedited. The average delivery time is 1 to 2 weeks, and each shipment can be fully tracked at www.ups.com. For international shipments, it is important to provide a valid phone number with your order. Most international shipments are delivered within 2 weeks. The only exceptions are when the customer has not provided a valid phone number and there are import duties which UPS needs to collect before making final delivery. In those cases, the package will be held at a nearby UPS Access Point until the customer either picks up the package in person or makes arrangements over the phone with UPS to release the package for final delivery. Our shipping charge only covers international postage. Import duties vary widely by country and are additional. We thoroughly clean all books that we offer for sale and do all basic book-repairs ourselves. Basic repairs include repairing slanted bindings, applying additional glue to hinges that have become excessively loose, hinge-tape repairs for damaged hinges, minor binding split repairs, gluing small tears in exterior of covers, removal (as much as possible) of black marker marks to covers of ex-library books, removal of smaller non-permanent stickers, straightening of minor bowing to covers or spine, and applying jacket protectors to books with torn or fragile jackets or for especially pristine or collectible books. We do not do major binding repairs, and any un-repairable binding splits or general weakness in binding will be noted. Any significant repairs such as a hinge-tape repair will also be noted. These repairs do not usually change the underlying condition grade, but do make the book more presentable. Some books are beyond help and will be listed as "Fair/Acceptable" or "Poor". Our books are graded conservatively with library books never graded above "Good" and used books rarely graded above "Very Good". Below is a list of the condition grades we use, in descending order: New/Fine Like New/Near Fine Very Good++ Very Good+ Very Good Minus Good++ Good+ Good Fair-to-Good Fair/Acceptable Poor Very Poor We try to grade accurately, but condition grades are often subjective, so please consider also any condition notes and book photos (when available) before placing an order. All book photos posted to our listings are actual photos of the book offered for sale and have been taken by us.…
Profil professionnel du vendeur
Salish Sea Books
WA, Etats-Unis
Conditions de vente
Thank you for taking an interest in one of our books. We are a mail-order only bookstore located in Bellingham, WA specializing in modern out-of-print books of all genres.
If you are an international customer, we ship internationally by UPS Worldwide Expedited. The average delivery time is 1 to 2 weeks, and each shipment can be fully tracked at www.ups.com. For international shipments, it is important to provide a valid phone number with your order. Most international shipments are delivered within 2 weeks. The only exceptions are when the customer has not provided a valid phone number and there are import duties which UPS needs to collect before making final delivery. In those cases, the package will be held at a nearby UPS Access Point until the customer either picks up the package in person or makes arrangements over the phone with UPS to release the package for final delivery. Our shipping charge only covers international postage. Import duties vary widely by country and are additional.
We thoroughly clean all books that we offer for sale and do all basic book-repairs ourselves. Basic repairs include repairing slanted bindings, applying additional glue to hinges that have become excessively loose, hinge-tape repairs for damaged hinges, minor binding split repairs, gluing small tears in exterior of covers, removal (as much as possible) of black marker marks to covers of ex-library books, removal of smaller non-permanent stickers, straightening of minor bowing to covers or spine, and applying jacket protectors to books with torn or fragile jackets or for especially pristine or collectible books.
We do not do major binding repairs, and any un-repairable binding splits or general weakness in binding will be noted. Any significant repairs such as a hinge-tape repair will also be noted. These repairs do not usually change the underlying condition grade, but do make the book more presentable. Some books are beyond help and will be listed as "Fair/Acceptable" or "Poor".
Our books are graded conservatively with library books never graded above "Good" and used books rarely graded above "Very Good". Below is a list of the condition grades we use, in descending order:
New/Fine
Like New/Near Fine
Very Good++
Very Good+
Very Good Minus
Good++
Good+
Good
Fair-to-Good
Fair/Acceptable
Poor
Very Poor
We try to grade accurately, but condition grades are often subjective, so please consider also any condition notes and book photos (when available) before placing an order.
All book photos posted to our listings are actual photos of the book offered for sale and have been taken by us.
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