Group Sequential Methods with Applications to Clinical Trials (Chapman & Hall/CRC Biostatistics Series)

Jennison, Christopher; Turnbull, Bruce W.

ISBN 10: 0849303168 ISBN 13: 9780849303166

Edit� par Chapman and Hall/CRC, 1999

Langue: anglais

Etat : Neuf Couverture rigide

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Titre

Group Sequential Methods with Applications to Clinical Trials (Chapman & Hall/CRC Biostatistics Series)

�diteur

Chapman and Hall/CRC

Date de parution

1999

Langue

anglais

ISBN � 10 chiffres

0849303168

ISBN � 13 chiffres

9780849303166

Reliure

Couverture rigide

�tat de l'article

New

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Synopsis

Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its findings. Group sequential methods provide a means to balance the ethical and financial advantages of stopping a study early against the risk of an incorrect conclusion. Group Sequential Methods with Applications to Clinical Trials describes group sequential stopping rules designed to reduce average study length and control Type I and II error probabilities. The authors present one-sided and two-sided tests, introduce several families of group sequential tests, and explain how to choose the most appropriate test and interim analysis schedule. Their topics include placebo-controlled randomized trials, bio-equivalence testing, crossover and longitudinal studies, and linear and generalized linear models. Research in group sequential analysis has progressed rapidly over the past 20 years. Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses. It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials. Medical statisticians engaged in any investigations planned with interim analyses will find this book a useful and important tool.

� propos de l?auteur

Christopher Jennison, Bruce W. Turnbull

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