Cystic Fibrosis has seen dramatic advances in treatment since the last edition, including targeted cystic fibrosis transmembrane conductance regulator (CFTR) protein modulators for most CFTR gene abnormalities. This new fifth edition is an update and expansion of the rapid clinical and scientific advances in improving prognosis, and the impact of COVID-19, all of which has transformed conventional models of care. It covers basic science, such as how detailed understanding of the biology of the CFTR gene and protein has led to novel and beneficial therapies, as well as all aspects of clinical management in high-, middle- and low-income settings and the voices of individuals with CF from across the world. It will be a useful reference for clinicians, including all levels of trainees, across the whole multidisciplinary team, scientists and students.
Key Features
- Follows an appealing organization of chapters, by developing fundamental knowledge of the reader before moving on to more complex or developing topics.
- Presents a comprehensive, authoritative and up-to-date text, integrating fundamental science and clinical aspects of cystic fibrosis providing an attractive read for clinicians, trainee doctors and scientists.
- Draws on global expertise and reflects best evidence-based practice from experts conducting cutting-edge clinical and basic science research from around the world.
Andrew Bush MD FHEA FRCP FRCPCH FERS FAPSR ATSFProfessor of Paediatrics and Paediatric Respirology, National Heart and Lung Institute, and Imperial Centre for Paediatrics and Child Health, Imperial College
Consultant Paediatric Chest Physician, Royal Brompton & Harefield NHS Foundation Trust
NIHR Senior Investigator Emeritus
Margarida D. Amaral
Professor
BioISI - Biosystems & Integrative Sciences Institute
Faculty of Sciences, University of Lisboa, Portugal
Jane C. Davies
Professor in Paediatric Respirology & Experimental Medicine.
Imperial College London
Honorary Consultant in Paediatric Respiratory Medicine
Royal Brompton Hospital, part of Guy's & St Thomas' NHS Foundation Trust
London
United Kingdom
Nicholas Simmonds MD(Res) FRCP
Associate Director Consultant Respiratory Physician
Adult Cystic Fibrosis Centre, Royal Brompton Hospital
Professor of Practice (Respiratory Medicine)
National Heart and Lung Institute, Imperial College London
Adult Cystic Fibrosis Centre, Royal Brompton Hospital
Sydney Street, London
United Kingdom
Jennifer L. Taylor-Cousar, MD, MSCS, ATSF
President, Medical Staff
Medical Director, Clinical Research Services
Co-Director and CF TDC Director, Adult CF Program
Professor, Departments of Medicine and Pediatrics,
Divisions of Pulmonary, Critical Care and Sleep Medicine and Pediatric Pulmonary Medicine
Divisions of Pulmonary Sciences and Critical Care Medicine and Pediatric Pulmonology
University of Colorado Anschutz Medical Campus
Sarath Ranganathan MBChB MRCP FRCPH FRACP PhD FThorSoc ATSF
Stevenson Chair and Head, Department of Paediatrics Academic Director of Clinical Education Strategy and Risk
University of Melbourne
Consultant, Respiratory and Sleep Medicine Royal Children's Hospital
Head, Respiratory Diseases Research Group Infection and Immunity Murdoch Children's Research Institute
