Immunodiagnostics and Patient Safety

Krystyna Sztefko

ISBN 10: 3110249472 / ISBN 13: 9783110249477

Edité par De Gruyter, Mercury Learning And Information Mai 2011, 2011

A propos de cet article

Neuware -Today most of immunochemistry methods for the determination of proteins, peptides, drugs, and many small molecules are fully automated, with good precision, excellent sensitivity and short reaction time. However, inaccuracy due to poor standardization and the presence of interfering substances in biological samples is still a serious and life-threatening issue. Proper validation of methods and quality assurance have little effect on frequency of occurrence of false positive or false negative results, which, if unrecognized, may lead to patient's misdiagnosis, unnecessary treatment or even unnecessary surgery. Deep knowledge of basic principles of immunochemical methods (antigen-antibody reaction, standardization, matrix effect, limit of detection, cross-reactivity, etc.), sources of analyte-independent interferences (preanalitycal errors, the presence of binding proteins, the presence of autoantibodies) and analyte-dependent interferences (presence of heterophilic antibodies, high-dose effect) are very important to understand, detect, reduce and/or eliminate the interferences. This book helps to reduce false results and, at the same time, improve patient's care and patient's safety.

N° de réf. du vendeur 9783110249477

Détails bibliographiques

• Titre: Immunodiagnostics and Patient Safety
• Éditeur: De Gruyter, Mercury Learning And Information Mai 2011
• Date de parution: 2011
• Langue: anglais
• ISBN à 10 chiffres: 3110249472
• ISBN à 13 chiffres: 9783110249477
• Reliure: Taschenbuch
• État de l'article: Neu
• Dimensions: 240 L x 170 H x 10 P (en millimètres) 240 millimètres de largeur par 170 millimètres de hauteur par 10 millimètres de profondeur
• Poids: 310 grammes

A propos de ce titre

Synopsis

Today most of immunochemistry methods for the determination of proteins, peptides, drugs, and many small molecules are fully automated, with good precision, excellent sensitivity and short reaction time. However, inaccuracy due to poor standardization and the presence of interfering substances in biological samples is still a serious and life-threatening issue. Proper validation of methods and quality assurance have little effect on frequency of occurrence of false positive or false negative results, which, if unrecognized, may lead to patient's misdiagnosis, unnecessary treatment or even unnecessary surgery. Deep knowledge of basic principles of immunochemical methods (antigen-antibody reaction, standardization, matrix effect, limit of detection, cross-reactivity, etc.), sources of analyte-independent interferences (preanalitycal errors, the presence of binding proteins, the presence of autoantibodies) and analyte-dependent interferences (presence of heterophilic antibodies, high-dose effect) are very important to understand, detect, reduce and/or eliminate the interferences. This book helps to reduce false results and, at the same time, improve patient's care and patient's safety.

À propos de l?auteur

Krystyna Sztefko, Jagiellonian University, Krakow, Poland.