An Inquiry into the Symptoms and Causes of the Syncope Anginosa, commonly called Angina Pectoris. [Bound with:] BUTTER, William. A Treatise on the Disease commonly called Angina Pectoris

THE FIRST TO MAKE THE CONNECTION BETWEEN ANGINA AND CORONARY HEART DISEASE. First edition, rare, of this work in which Parry was the first to make the connection between angina and coronary heart disease. "In this important contribution to the understanding of the coronary circulation, Parry . reports on several patients suffering from what he termed 'syncope anginosa' and concludes that the condition is caused by disease of the coronary arteries" (Heirs of Hippocrates). He remarked in his case notes that angina most often occurred in obese males over 50 and his autopsies showed calcification in the coronary arteries. He read his paper on the topic before the Gloucester Medical Society in 1788 and it was published in 1799 as the offered work. Parry delayed publication because Edward Jenner had diagnosed John Hunter as having angina pectoris and Parry did not want to alarm his mentor Hunter with the detailed information included in this work; Parry actually treated Hunter for angina - he died in 1793. This is now recognized as Parry's major contribution to medicine, although it was ignored for more than a hundred years. Parry suggested that to prevent coronary artery disease, his patients should eat and drink in moderation (avoiding 'flesh meats') and exercise, but he doubted that his advice would be heeded. Parry's work reprints (pp. 3-5) a letter from Jenner describing his treatment of some patients with angina pectoris. Parry had met Jenner in grammar school and they remained friends for life. They both became physicians who spoke, wrote or collaborated on some of the same topics, among them, vaccination and cardiology. Jenner dedicated his great work Inquiry into the Causes and Effects of the VariolaeVaccinae (1798) to "C.H. Parry, M.D., at Bath, My Dear Friend." When Parry died six years after suffering a paralytic stroke, Jenner was one of the pall bearers. The second work in the volume was first published in 1791. It is very rare on the market. ABPC/RBH list only five other copies of the Parry at auction since Norman. All of these except the Friedman copy (Sotheby's New York, November 16, 2001, lot 137, $34,100) were ex-library. "At the very close of the eighteenth century there was published in Bath a slim volume with the title An inquiry into the symptoms and causes of the syncope anginosa, commonly called angina pectoris; illustrated by dissections (1799). Its author, Caleb Hillier Parry, is known for his sagacity and observational acuity, which among other things led him to produce the first observations on exophthalmic goitre. His is the first volume exclusively devoted to our subject which also deals with the anatomy and pathophysiology of the myocardium. Much influenced by Jenner, whose letter he quotes in the Introduction, Parry is also a strong adherent of the coronary hypothesis. In a 'dissertation' which he read in 1788, he states, 'Angina Pectoris is a disease of the heart, connected with mal-organization of the coronary arteries.' "Chaper 2 is entitled 'Cases and Dissections.' Three cases were described in greater detail, all of them showing a more protracted type of disease, though death, when it occurred eventually, was sudden. The post-mortem findings refer to ossification and partial obstruction of the coronaries, and to gross pathology of the aorta. No morbid changes of the myocardium are reported. However, the description of the clinical features is extraordinarily well-presented. "Chapter 3 begins with a historical survey. Seneca's case is mentioned first, but the author regards it rather as a disorder of respiration - a view shared by modern historians. As to Morgagni, Parry found the case discussed in his Epistle 26 (13) the only one bearing a relation to any example of the disease before Heberden's time. He doubts whether Morgagni's cases 16 (43) and 17 (17) belong to the angina pectoris group, since they are complicated by other diseases of the pericardium, aorta, and so on . "Unlike Heberden, Par. …