Insulin-like Growth Factor Receptor Signalling (Molecular Biology Intelligence Unit)

ISBN 10: 0306478463 / ISBN 13: 9780306478468

Edité par Springer, 2003

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N° de réf. du vendeur ria9780306478468_new

Détails bibliographiques

• Titre: Insulin-like Growth Factor Receptor Signalling (Molecular Biology Intelligence Unit)
• Éditeur: Springer
• Date de parution: 2003
• Langue: anglais
• ISBN à 10 chiffres: 0306478463
• ISBN à 13 chiffres: 9780306478468
• Reliure: Couverture rigide
• État de l'article: New

A propos de ce titre

Synopsis

Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets.
This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.

Présentation de l'éditeur

Signal transduction is one of the most exciting research areas in modern biology as it deals with how information flows from the extracellular environment into a living cell to change its metabolism, genotype and phenotype. With the completion of the genomes of human and several other species, it becomes even more important to elucidate the molecular mechanisms that govern cellular functions. The intracellular signaling network, which is composed of many signaling pathways, regulates most, if not all, fundamental cellular activities, from proliferation to programmed cell death (apoptosis). Over the past decade, many signaling pathways have been “mapped’ out. Nowadays, we know in great detail about how a specific signal is transmitted via specific signaling pathways, from the membrane to the nucleus, to change the functions of a cell. In this book, a group of experts present a comprehensive review of one of such signaling pathways, the JNK signaling pathway.