Killer Cell Dynamics : Mathematical and Computational Approaches to Immunology

Dominik Wodarz

ISBN 10: 0387308938 / ISBN 13: 9780387308937

Edité par Springer New York, 2006

A propos de cet article

Druck auf Anfrage Neuware - Printed after ordering - Systems biology and computational biology have recently become prominent areas of research in the biomedical community, especially in the area of cell biology. Given that much information on genes and their protein products has become available, the big question is how the individual components interact and work together, and how this determines the functioning of cells, organs, and organisms. Long before the popularity of systems biology in biomedicine, however, such approaches have been used successfully in a di erent area of biology: population ecology. Research in the area of population dynamics - vestigated complex interactions between di erent populations of organisms, such as the dynamics of competition and predation, food webs, community structure, as well as the epidemiology of infectious diseases. In this eld, t- oretical biology and mathematical modeling have become an integral part of research. Mathematical models allowed people to obtain interesting and counter-intuitive insights into how complex interactions among di erent p- ulations can play out. Such mathematical studies not only gave rise to - teresting theoretical ideas, but also provided the basis for the design of new experimental work and de ned major questions and directions of research. Around 1990, such population dynamic concepts, and the use of mathema- cal/computational approaches, started to be applied to the in vivo dynamics between viruses and the immune system. These interactions have many s- ilarities to ecological, epidemiological, and evolutionary principles. Consider theepidemiologicalspreadofapathogen(suchasthecommoncold)througha population of hosts.

N° de réf. du vendeur 9780387308937

Détails bibliographiques

• Titre: Killer Cell Dynamics : Mathematical and Computational Approaches to Immunology
• Éditeur: Springer New York
• Date de parution: 2006
• Langue: anglais
• ISBN à 10 chiffres: 0387308938
• ISBN à 13 chiffres: 9780387308937
• Reliure: Buch
• État de l'article: Neu
• Dimensions: 243 L x 162 H x 17 P (en millimètres) 243 millimètres de largeur par 162 millimètres de hauteur par 17 millimètres de profondeur
• Poids: 450 grammes

A propos de ce titre

Synopsis

This book shows how mathematical and computational approaches can be useful to help us understand how killer T-cell responses work to fight viral infections. It also demonstrates that such mathematical and computational approaches are most valuable when coupled with experimental work through collaborations. The interdisciplinary spirit of the research and analysis is reflected in the writing style of the book. While the topic of the book is mathematical modeling, the text is written in such a way that experimental immunologists and virologists without extensive computational background will be able to understand the arguments, and to see the biological implications of theory. The book covers a broad variety of topics, including both basic immunological questions and the application of these insights to the understanding and treatment of pathogenic human diseases.