Liposomes: Methods and Protocols, Volume 1: Pharmaceutical Nanocarriers (Methods in Molecular Biology (605))

ISBN 10: 1493957082 / ISBN 13: 9781493957088

Edité par Humana Press, 2016

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Détails bibliographiques

• Titre: Liposomes: Methods and Protocols, Volume 1: Pharmaceutical Nanocarriers (Methods in Molecular Biology (605))
• Éditeur: Humana Press
• Date de parution: 2016
• Langue: anglais
• ISBN à 10 chiffres: 1493957082
• ISBN à 13 chiffres: 9781493957088
• Reliure: Couverture souple
• État de l'article: New

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Synopsis

Efforts to describe and model the molecular structure of biological membranes go back to the beginning of the last century. In 1917, Langmuir described membranes as a layer of lipids one molecule thick [1]. Eight years later, Gorter and Grendel concluded from their studies that "the phospholipid molecules that formed the cell membrane were arranged in two layers to form a lipid bilayer" [2]. Danielli and Robertson proposed, in 1935, a model in which the bilayer of lipids is sequestered between two monolayers of unfolded proteins [3], and the currently still accepted fuid mosaic model was proposed by Singer and Nicolson in 1972 [4]. Among those landmarks of biomembrane history, a serendipitous observation made by Alex Bangham during the early 1960s deserves undoubtedly a special place. His fnding that exposure of dry phospholipids to an excess of water gives rise to lamellar structures [5] has opened versatile experimental access to studying the biophysics and biochemistry of biological phospholipid membranes. Although during the following 4 decades biological membrane models have grown in complexity and functionality [6], liposomes are, besides supported bilayers, membrane nanodiscs, and hybrid membranes, still an indisputably important tool for membrane b- physicists and biochemists. In vol. II of this book, the reader will fnd detailed methods for the use of liposomes in studying a variety of biochemical and biophysical membrane phenomena concomitant with chapters describing a great palette of state-of-the-art analytical technologies.