MICROBIAL GENE ESSENTIALITY: PROTOCOLS AND BIOINFORMATICS

OSTERMAN,A.L., GERDES,S.Y.

ISBN 10: 1588293785 / ISBN 13: 9781588293787

Edité par SPRINGER, 2008

A propos de cet article

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N° de réf. du vendeur AD 9781588293787

Détails bibliographiques

• Titre: MICROBIAL GENE ESSENTIALITY: PROTOCOLS AND BIOINFORMATICS
• Éditeur: SPRINGER
• Date de parution: 2008
• Langue: anglais
• ISBN à 10 chiffres: 1588293785
• ISBN à 13 chiffres: 9781588293787
• Reliure: Hardcover
• État de l'article: New

A propos de ce titre

Synopsis

This collection of experimental and computational strategies and techniques for microbial genome-scale essentiality studies was developed and written by the leading research groups in the field. In addition to wet-lab protocols, the book describes statistical methods essential for planning and evaluating successful large-scale essentiality screens; in-silico prediction of gene essentiality using genome-scale reconstructed metabolic models; and data integration and comparative analysis of genomic databases. Each protocol follows the successful Methods in Molecular Biology(TM) series format, offering an introduction outlining the underlying principles, step-by-step instructions, a list of necessary equipment and reagents, and tips on troubleshooting and avoiding pitfalls.