Macro Roles for MicroRNAs in the Life and Death of Neurons

De Strooper, Bart (Edited by)

ISBN 10: 364226204X / ISBN 13: 9783642262043

Edité par Springer, 2012

A propos de cet article

2010 edition. 133 pages. 9.20x6.10x0.39 inches. In Stock.

N° de réf. du vendeur x-364226204X

Détails bibliographiques

• Titre: Macro Roles for MicroRNAs in the Life and Death of Neurons
• Éditeur: Springer
• Date de parution: 2012
• Langue: anglais
• ISBN à 10 chiffres: 364226204X
• ISBN à 13 chiffres: 9783642262043
• Reliure: Paperback
• État de l'article: Brand New
• Poids: 0,2 kilogramme

A propos de ce titre

Synopsis

The discovery of microRNAs has revealed an additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. This book examines this field.

Présentation de l'éditeur

The discovery of microRNAs has revealed an unexpected and spectacular additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. Since the initial studies performed in C.elegans, we gave gone a far way to begin to understand how microRNA pathways can have an impact on health and disease in human. Although microRNAs are abundantly expressed in the brain, relatively little is known about the multiple functions of these RNA molecules in the nervous system. Nevertheless, we know already that microRNA pathways play major roles in the proliferation, differentiation, function and maintenance of neuronal cells. Several intriguing studies have linked microRNAs as major regulators of the neuronal phenotype, and have implicated specific microRNAs in the regulation of synapse formation and plasticity. Dysfunction of microRNA pathways is also slowly emerging as a potential important contributor to the pathogenesis of major neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. These novel insights appear to be particular promising for the understanding of the very frequent and badly understood sporadic forms of these diseases as compared to the genetic forms. Thus, the better understanding of the implications of this novel field of molecular biology is crucial for the broad area of neurosciences, from the fundamental aspects to the clinic, and from novel diagnostic to potentially therapeutic applications for severe neurological and maybe psychiatric diseases.