Macro Roles for MicroRNAs in the Life and Death of Neurons

Bart De Strooper

ISBN 10: 364204297X / ISBN 13: 9783642042973

Edité par Springer Berlin Heidelberg Dez 2009, 2009

A propos de cet article

This item is printed on demand - it takes 3-4 days longer - Neuware -The discovery of microRNAs has revealed an unexpected and spectacular additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. Since the initial studies performed in C.elegans, we have gone a far way to begin to understand how microRNA pathways can have an impact on health and disease in human. Although microRNAs are abundantly expressed in the brain, relatively little is known about the multiple functions of these RNA molecules in the nervous system. Nevertheless, we know already that microRNA pathways play major roles in the proliferation, differentiation, function and maintenance of neuronal cells. Several intriguing studies have linked microRNAs as major regulators of the neuronal phenotype, and have implicated specific microRNAs in the regulation of synapse formation and plasticity. Dysfunction of microRNA pathways is also slowly emerging as a potential important contributor to the pathogenesis of major neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. These novel insights appear to be particular promising for the understanding of the very frequent and badly understood sporadic forms of these diseases as compared to the genetic forms. Thus, the better understanding of the implications of this novel field of molecular biology is crucial for the broad area of neurosciences, from the fundamental aspects to the clinic, and from novel diagnostic to potentially therapeutic applications for severe neurological and maybe psychiatric diseases. 136 pp. Englisch.

N° de réf. du vendeur 9783642042973

Détails bibliographiques

• Titre: Macro Roles for MicroRNAs in the Life and Death of Neurons
• Éditeur: Springer Berlin Heidelberg Dez 2009
• Date de parution: 2009
• Langue: anglais
• ISBN à 10 chiffres: 364204297X
• ISBN à 13 chiffres: 9783642042973
• Reliure: Buch
• État de l'article: Neu
• Dimensions: 241 L x 160 H x 14 P (en millimètres) 241 millimètres de largeur par 160 millimètres de hauteur par 14 millimètres de profondeur
• Poids: 377 grammes

A propos de ce titre

Synopsis

Macro Roles for MicroRNAs in the Life and Death of Neurons

Présentation de l'éditeur

The discovery of microRNAs has revealed an unexpected and spectacular additional level of fine tuning of the genome and how genes are used again and again in different combinations to generate the complexity that underlies for instance the brain. Since the initial studies performed in C.elegans, we gave gone a far way to begin to understand how microRNA pathways can have an impact on health and disease in human. Although microRNAs are abundantly expressed in the brain, relatively little is known about the multiple functions of these RNA molecules in the nervous system. Nevertheless, we know already that microRNA pathways play major roles in the proliferation, differentiation, function and maintenance of neuronal cells. Several intriguing studies have linked microRNAs as major regulators of the neuronal phenotype, and have implicated specific microRNAs in the regulation of synapse formation and plasticity. Dysfunction of microRNA pathways is also slowly emerging as a potential important contributor to the pathogenesis of major neurodegenerative disorders such as Alzheimer s disease and Parkinson s disease. These novel insights appear to be particular promising for the understanding of the very frequent and badly understood sporadic forms of these diseases as compared to the genetic forms. Thus, the better understanding of the implications of this novel field of molecular biology is crucial for the broad area of neurosciences, from the fundamental aspects to the clinic, and from novel diagnostic to potentially therapeutic applications for severe neurological and maybe psychiatric diseases.