Molecular Components of Hepatitis B Virus

M. Feitelson

ISBN 10: 0898386969 / ISBN 13: 9780898386967

Edité par Springer US, Springer US, 1985

A propos de cet article

Druck auf Anfrage Neuware - Printed after ordering - Since the discovery of Australia antigen and its association with type B hepatitis, molecular characterization of the components making up hepatitis B virus (RBV) have been pursued with worldwide interest. Over the past two decades, such characterization has led to the development of sensitive assays to screen and exclude contaminated units from blood banks and has recently resulted in the licensing of several RBV vaccines. That more than 200 million people worldwide are chronically infected with RBV, and that they are at a high risk for the development of chronic hepatitis and hepatocellular carcinoma, still represent formidable problems in our understanding of host-virus relationships on the molecular level. In the absence of a suitable tissue culture system, and with a very limited host range of infection, characterization of RBV on the molecular level has made remarkable progress recently with the advent of genome cloning, sequencing and expression of individual virus genes by recombinant DNA technology. The presence of hepatitis B-like viruses in an expanding number of animal hosts, and the possibility of virus replication in cells other than hepatocytes, provide great promise that future work will elucidate the molecular mechanisms operative in the various outcomes of RBV infection.

N° de réf. du vendeur 9780898386967

Détails bibliographiques

• Titre: Molecular Components of Hepatitis B Virus
• Éditeur: Springer US, Springer US
• Date de parution: 1985
• Langue: anglais
• ISBN à 10 chiffres: 0898386969
• ISBN à 13 chiffres: 9780898386967
• Reliure: Buch
• État de l'article: Neu
• Dimensions: 241 L x 160 H x 21 P (en millimètres) 241 millimètres de largeur par 160 millimètres de hauteur par 21 millimètres de profondeur
• Poids: 603 grammes

A propos de ce titre

Synopsis

Since the discovery of Australia antigen and its association with type B hepatitis, molecular characterization of the components making up hepatitis B virus (RBV) have been pursued with worldwide interest. Over the past two decades, such characterization has led to the development of sensitive assays to screen and exclude contaminated units from blood banks and has recently resulted in the licensing of several RBV vaccines. That more than 200 million people worldwide are chronically infected with RBV, and that they are at a high risk for the development of chronic hepatitis and hepatocellular carcinoma, still represent formidable problems in our understanding of host-virus relationships on the molecular level. In the absence of a suitable tissue culture system, and with a very limited host range of infection, characterization of RBV on the molecular level has made remarkable progress recently with the advent of genome cloning, sequencing and expression of individual virus genes by recombinant DNA technology. The presence of hepatitis B-like viruses in an expanding number of animal hosts, and the possibility of virus replication in cells other than hepatocytes, provide great promise that future work will elucidate the molecular mechanisms operative in the various outcomes of RBV infection.