Monoclonal Antibodies to Receptors: Probes for Receptor Structure and Function [Receptors and Recognition., Volume 17]

Greaves, M. F., ed.

ISBN 10: 0412253305 / ISBN 13: 9780412253300

Edité par Chapman and Hall, London / New York., 1984

8vo, hardcover. No dj. Good condition. Ex-lib copy w/ markings to opening pgs, text-block edges lightly stamped, rear pocket & spine label neatly removed; contents clean, binding firm. xii, 324 p., illus. N° de réf. du vendeur 1100928.17

Synopsis :

Receptor specific antibodies are excellent probes for a wide range of biological investigations on receptor structure and function. The hybridoma technology (Kohler and Milstein, 1975) has inevitably had a major impact on this field with most of the better known receptors now identified with monoclonal antibodies. This volume of the Receptors and Recognition series provides reviews of recent developments in this field and emphasizes in particular the new opportunities afforded by the judicious application of monoclonal reagents. It is assumed that most readers will be familiar with the now fairly routine methods of cell fusion, hybridoma cloning and selection for producing monoclonal antibodies and so few details of the basic technical procedures are described. Several good reviews on this topic are however available (see Galfre and Milstein, 1981; Goding, 1980; Yelton and Scharf, 1981; McMichael and Fabre, 1982). By no means all vertebrate receptor species are discussed here; omissions include antibodies to low density lipoprotein receptors (Beisiegel et al., 1981; Kita et al., 1981), prolactin and growth hormone receptors (Friesen etal., 1982; Simpson et al., 1983) and the hepatocyte asialoglycoprotein receptor (Schwartz et al., 1981; Harford et al., 1982). Nevertheless the coverage is comprehensive and critical and the individual chapters provided illustrate vividly the rapid progress being made.

Détails bibliographiques

Titre : Monoclonal Antibodies to Receptors: Probes ...
Éditeur : Chapman and Hall, London / New York.
Date d'édition : 1984
Reliure : Hardcover
Etat : Good