New Approaches in Cancer Pharmacology: Drug Design and Development.. Cet article n’est pas disponible.New Approaches in Cancer Pharmacology: Drug Design and Development.

The development of new drugs for the treatment of cancer is both medically important and scientifically challenging. The monograph looks at some of the most exciting prospects, e.g., future clinilcal trials, new biological discoveries, and advances in molecular biology. This volume will be of interest to laboratory scientists in the academic sector and the pharmaceutical industry, as well as to medical professionals. The particalar topic covered are: - Experimental models to investigate novel anticancer drugs - Principles in the design of DNA-interactive molecules - Discovery of improved platinum analogues - Pharmacological intervention with signal transduction - Discovery, and design of inhibitors of oncogenic tyrosine kinases. Apoptosis and cancer therapy - Engineering antibodies for targeted cancer therapy

This monograph is the first of two dealing with selected topics in the area of the design and development of new anticancer drugs. Its purpose is to present a collection of opinions from international experts in the field, with the aim of stimulating the further development of new drugs on a rational basis. The topic is treated in a lively way. The reviews focus on the very latest developments in key areas, concentrating on the exciting developments, controversies and future trends. They are not long histrical reviews, but nevertheless do provide the appropriate background and references. However, emphasis is on the state of the art. In this respect the approach is quite different from other books in the area. Readers, including particularly scientists and doctors interested in cancer drug, will find this useful as an up to date source of current opinion and debate. It will be suitable for experts in the field, but also accessible to research students for example. They should find it a valuable reference for the latest developments and particularly the controversial areas in the field. It is designed to promote and encourage further debate and to influence the research community. The particular topics covered are: DNA sequence and gene specific drugs - Antisense and antigene oligonucleotides targeted to oncogenes - Prospects of biological and gene therapies - Membrane and signal transduction targets - Design of novel anti-endocrine agents -Therapeutic monitoring and dose optimization in oncology - Screening for new anti-tumour drugs