Nitric Oxide in Health and Disease
Langue : anglais
Edité par Elsevier Science Publishing Co Inc, 2023
- Livre broché
- Neuf
Vendeur : PBShop.store UK, Fairford, GLOS, Royaume-UniPBShop.store UK
Vendeur AbeBooks depuis 11 juin 1999
Etat: Neuf
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Quantité disponible : 1 disponible
Ajouter au panierA propos de cet article
New Book. Shipped from UK. Established seller since 2000.
N° de réf. du vendeur GB-9780443133428
- Titre
- Nitric Oxide in Health and Disease
- Auteur
- Bonavida, Benjamin
- Éditeur
- Elsevier Science Publishing Co Inc
- Année de publication
- 2023
- État de l'article
- New
- Reliure
- PAP
- Langue
- anglais
- ISBN à 10 chiffres
- 0443133425
- ISBN à 13 chiffres
- 9780443133428
- Poids de l'article
- 738 grammes
Nitric Oxide in Health and Disease: Therapeutic Applications in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities. The book discusses many examples of research related to the application of novel therapeutic compounds that focus on a chemical--nitric oxide--and its applications that have been shown to exert significant therapeutic activities against various resistant cancers unresponsive to current treatments and different inflammatory diseases which continue to require novel treatments.
This is a valuable resource for cancer researchers, oncologists, graduate students and researchers from medical and biomedical fields who want to know more about NO and its therapeutic applications in cancer and inflammatory diseases.
« Synopsis » peut appartenir à une autre édition de cet ouvrage.
À propos de l’auteur
Dr. Benjamin Bonavida is currently a Distinguished Research Professor at the University of California, Los Angeles (UCLA). He is affiliated with the Department of Microbiology, Immunology and Molecular Genetics, UCLA David Geffen School of Medicine, and the Jonsson Comprehensive Cancer Center at UCLA. His research career, thus far, has focused on investigations in the fields of basic immunochemistry and cancer immunobiology. His research investigations have ranged from the biochemical, molecular, and genetic mechanisms of cell-mediated killing and tumor cell resistance to chemo-immuno cytotoxic drugs. The reversal of tumor cell resistance was investigated by the use of various selected sensitizing agents based on molecular mechanisms of resistance. In these investigations, there was the newly characterized dysregulated NF-kB/ Snail/YY1/RKIP/PTEN loop in many cancers that was reported to regulate cell survival, proliferation, invasion, metastasis, and resistance. Emphasis was focused on the roles of the tumor suppressor Raf kinase inhibitor protein (RKIP) and the tumor promoter Yin Yang 1 (YY1) and the role of nitric oxide (NO) as a chemo-immuno-sensitizing factor. Many of the aforementioned studies are centered on the clinical challenging features of cancer patients' failure to respond to both conventional and targeted therapies.
Dr. Bonavida has been active in the organization of regular sequential international miniconferences that are highly focused on the roles of YY1, RKIP, and nitric oxide in cancer and their potential therapeutic applications. Several books edited or coedited have been published. In addition, he is the Series Editor of books (over 20) published by Springer/Nature: Resistance to Anti-Cancer Targeted Therapeutics. In addition, he is presently the Series Editor of Three Series published by Elsevier/Academic Press on "Cancer Sensitizing Agents for Chemotherapy," "Sensitizing Agents for Cancer Resistance to Cell Mediated Immunotherapy," and "Breaking Tolerance to Anti-Cancer Antibody Immunotherapy." He is the Editor-in-Chief of the Journal Critical Reviews in Oncogenesis, Editor-in-Chief of Onco Therapeutics, and Associate Editor of "Critical Reviews in Immunology." Dr. Bonavida has published over 500 research publications and reviews in various scientific journals of high impact.
Dr. Muntané's scientific career has been all devoted to the study of the relevance of oxidative and nitrosative stress in cell proliferation and death in different experimental models and clinical settings such as acute hepatocellular injury and hepatocarcinoma. The relevance of the temporal, dose and compartmentalization of nitric oxide (NO) release has been related to cytotoxicity, as well as the cytoprotective properties of classical antioxidants, prostanoids and alpha-tocopherol in different experimental models of liver injury. The anti-tumoral properties of NO has also been demonstrated using NO-donors and nitric oxide synthase type III (NOS3) overexpression in in vivo and in vitro models. The involvement of NO in the antitumoral properties of the molecular recommended therapies for patients with advanced hepatocarcinoma, such as the tyrosine kinase inhibitor Sorafenib, has also been studied comprehensively by Dr. Muntané's lab.
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PBShop.store UK
Fairford, GLOS, Royaume-Uni
Vendeur AbeBooks depuis 11 juin 1999
Frais d'expédition de Royaume-Uni vers Etats-Unis
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