Nitrogen Heterocycles in Neurodegenerative Disorders

Neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, represent a rapidly escalating global health burden with limited disease-modifying therapies. Advances in medicinal chemistry have highlighted nitrogen-containing heterocycles as powerful scaffolds in the search for effective neuroprotective agents. Their structural diversity, target specificity, and favorable pharmacological profiles position them at the forefront of next-generation drug discovery.

Nitrogen Heterocycles in Neurodegenerative Disorders: Chemistry and Therapeutic Potential deliver a comprehensive and research-driven exploration of the chemistry, biological relevance, and translational promise of nitrogen-based heterocyclic compounds. Distinct in its integrative approach, the book bridges synthetic chemistry, molecular pharmacology, and clinical perspectives. It not only discusses established heterocyclic frameworks but also critically evaluates emerging scaffolds, structure–activity relationships, and challenges in blood–brain barrier penetration—offering readers both foundational knowledge and forward-looking insights.

Key Features:

? Detailed overview of neurodegenerative disease pathophysiology

? Exploration of molecular targets and signaling pathways

? Design, synthesis, and SAR studies of key nitrogen heterocycles

? Pharmacokinetic and pharmacodynamic considerations for CNS drugs

? Future perspectives on heterocycle-based neurotherapeutics

This volume serves as an essential reference for medicinal chemists, pharmaceutical scientists, neuroscientists, clinicians, and postgraduate researchers seeking a deeper understanding of heterocyclic strategies in combating neurodegeneration.

Dr. Shraddha Manish Gupta has more than 18 years of research and teaching experience and currently is an Assistant Professor-SG at School of Health Sciences and Technology, UPES, Dehradun, India. She has completed B.Pharm and M.Pharm from NDMVP’S College of Pharmacy, Nasik (M.H.) in 2003, 2006 respectively and Ph.D from Oriental University Indore, India. She Secured 96 percentile in GATE-2004 conducted by IIT, Delhi. She worked as a Research Assistant in School of Pharmacy, Monash University, Malaysia. She was Mentor in CSIR-SRTP (2020) program under Interdisciplinary Approach for Sustainable Use of Resources project-13. She has written more than 12 articles published in Q1 international journals, 2 patents (1 granted, 1published), 2 edited books with CRC publisher and 12 book chapters. She is a member of various professional and academic bodies like, Life Membership of Association of Pharmaceutical Teachers of India (APTI), Indian Pharmaceutical Association (IPA) and Indian Society of Chemists and Biologists (ISCB)

Dr. Somdutt Mujwar is a passionate and dedicated researcher in the field of computational and pharmaceutical chemistry, specializing in drug discovery and development. With a Ph.D. in Bioinformatics, he has made significant contributions to understanding the molecular mechanisms underlying cancer, neurodegenerative, and infectious diseases. Dr. Mujwar's research focuses on exploring the therapeutic potential of natural compounds in treating cancer and neurodegenerative disorders. His work has been published in numerous peer-reviewed journals, showcasing his expertise and dedication to advancing scientific knowledge. Beyond his research endeavours, Dr. Mujwar is committed to education and mentorship. He actively engages in teaching and training programs, guiding aspiring scientists and pharmacists towards academic and professional success.

Driven by a desire to translate scientific discoveries into practical solutions, Dr. Mujwar collaborates with multidisciplinary teams to develop innovative approaches to drug design and delivery. His interdisciplinary approach and collaborative spirit have earned him recognition as a leader in the field. Overall, Dr. Somdutt Mujwar's expertise, dedication, and commitment to scientific excellence make him an asset to the field of pharmaceutical sciences, with a profound impact on the advancement of drug discovery and development.

Dr. Kamal Shah has more than 18 years of research and teaching experience and currently working as Professor at the Institute of Pharmaceutical Research, GLA University, Mathura, India. He completed B.Pharma from Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal (M.P.) in 2003. He was gold medalist in B.Pharm., M.Pharm. from the Department of Pharmaceutical Sciences, Sagar University, Sagar, India and PhD from APJ Kalam University Lucknow, India. He has written more than 90 articles published in national and international journals, 20 book chapters and 05 edited books. His SCOPUS h index is 17, with 905 citations.

Dr. Nagendra Singh Chauhan obtained his M.Pharm, Ph.D from Department of Pharmaceutical sciences, Dr. H.S. Gour University, Sagar in 2006 and 2011. He has around 14 years of research experience. He is presently working as Senior Scientific Officer Grade-II and Government Analyst at Drugs Testing Laboratory avam Anusandhan Kendra, Raipur, Chhattisgarh, India. He has professional Expertise in Natural Product Isolation and phytopharmacology. He has written more than 76 articles published in national and international journals, 35 book chapters and edited seven books in publishers like Academic Press,CRC and Willey. Recently edited book entitled “Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents” and “Natural Products in Vector Borne Disease Management: Published by Academic press. He has written more than 75 articles published in national and international journals, 32 book chapters and edited five books. He has citations of more than 2700 with h-index 42 and i10 index of 38 (Google scholar) and Scopus h-index 15; 669 citations. He is a member of various professional and academic bodies like Society of Pharmacognosy India, International Natural Product Sciences Taskforce (INPST) society, SILAE: SocietàItalo-Latinoamericana di Etnomedicina (The Scientific Network on Ethnomedicine, Italy), Institutional Human ethical committee, Association of Pharmaceutical Teachers of India (APTI) and Indian Pharmacy Graduates' Association.