Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease
. Ed(s): Lincoff, A. Michael
ISBN 10: 1617374083 ISBN 13: 9781617374081
Edité par Humana Press Inc., 2010
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Description :
Editor(s): Lincoff, A. Michael. Series: Contemporary Cardiology. Num Pages: 486 pages, biography. BIC Classification: MJD. Category: (P) Professional & Vocational. Dimension: 254 x 178 x 24. Weight in Grams: 920. . 2010. 2nd ed. Softcover of orig. ed. 2003. Paperback. . . . . Books ship from the US and Ireland. N° de réf. du vendeur V9781617374081
Synopsis :
One of the most important developments in the field of cardiovascular medicine over the last two decades has been recognition of the key role played by arterial thrombosis in the pathogenesis of acute coronary syndromes, ischemic complications of percutane- ous coronary revascularization, and coronary and peripheral atherosclerosis. The phar- macologic armamentarium directed against vascular thrombosis has thus expanded substantially during that time, with development of new fibrinolytic agents, low-molecu- lar-weight heparins, direct thrombin inhibitors, antagonists to platelet activation, and the platelet glycoprotein lIb/IlIa inhibitors. Though clinical investigations of these com- pounds have been marked by failures as well as successes, there is little doubt that enhanced antithrombotic therapies have markedly improved the outcome of patients undergoing coronary revascularization or with acute coronary syndromes. Glycoprotein IIblIlIa receptor antagonists were introduced into clinical practice to overcome the limitations of approaches that inhibit only individual pathways of platelet activation. Multiple mechanisms of platelet activation in response to different agonists converge on the platelet membrane glycoprotein IIblIlIa complex, the "final common pathway" of platelet aggregation. The clinical hemorrhagic syndrome caused by a rare inherited defect in this receptor (Glanzmann' s thrombasthenia), characterized by muco- cutaneous and postsurgical bleeding, but infrequent spontaneous organ (particularly central nervous system) bleeding, suggested that therapeutic inhibition of this receptor might be a potent, yet well-tolerated means of treating thrombotic disorders.
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Titre : Platelet Glycoprotein IIb/IIIa Inhibitors in...
Éditeur : Humana Press Inc.
Date d'édition : 2010
Reliure : Couverture souple
Etat : New
Edition : 2ème Édition
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Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Part I. Basic Principles Thrombosis in Acute Coronary Syndromes and Coronary Interventions Thaddeus R. Tolleson and Robert A. Harrington Platelet Adhesion Edward F. Plow Glycoprotein IIb/IIIa in Platelet Aggregation and Acute Arterial Thrombosis Patrick . N° de réf. du vendeur 4256822
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Taschenbuch. Etat : Neu. Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease | A. Michael Lincoff | Taschenbuch | x | Englisch | 2010 | Humana Press | EAN 9781617374081 | Verantwortliche Person für die EU: Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. N° de réf. du vendeur 107146599
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Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A. Michael Lincoff takes advantage of critically important new knowledge arising from recent clinical trials to update and expand his acclaimed Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease. This substantially enhanced Second Edition contains new chapters on the role of GPIIb/IIIa blockade during acute coronary syndromes, on outcomes with chronic oral GPIIb/IIIa blockade following acute coronary syndromes, and on fibrinolytic therapy during acute myocardial infarctions. Additional enhancements include revised findings from the latest trials of GPIIb/IIIa inhibition during percutaneous coronary intervention, discussion of GPIIb/IIIa blockade with other platelet and thrombin inhibitors, and a review of the potential effects beyond inhibition of platelet aggregation. The book also explains the scientific basis of this therapy, evaluates its benefits and risks for patients, and summarizes detailed data from its various clinical trials. Comprehensive and definitive, Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease, Second Edition offers physicians, cardiologists, emergency room doctors, and basic scientists a complete and authoritative review of the state-of-the-art in glycoprotein IIb/IIIa receptor inhibitor use today. 488 pp. Englisch. N° de réf. du vendeur 9781617374081
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Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease
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Humana Press, Humana Press Nov 2010, 2010
ISBN 10 : 1617374083
ISBN 13 : 9781617374081
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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -One of the most important developments in the field of cardiovascular medicine over the last two decades has been recognition of the key role played by arterial thrombosis in the pathogenesis of acute coronary syndromes, ischemic complications of percutane ous coronary revascularization, and coronary and peripheral atherosclerosis. The phar macologic armamentarium directed against vascular thrombosis has thus expanded substantially during that time, with development of new fibrinolytic agents, low-molecu lar-weight heparins, direct thrombin inhibitors, antagonists to platelet activation, and the platelet glycoprotein lIb/IlIa inhibitors. Though clinical investigations of these com pounds have been marked by failures as well as successes, there is little doubt that enhanced antithrombotic therapies have markedly improved the outcome of patients undergoing coronary revascularization or with acute coronary syndromes. Glycoprotein IIblIlIa receptor antagonists were introduced into clinical practice to overcome the limitations of approaches that inhibit only individual pathways of platelet activation. Multiple mechanisms of platelet activation in response to different agonists converge on the platelet membrane glycoprotein IIblIlIa complex, the 'final common pathway' of platelet aggregation. The clinical hemorrhagic syndrome caused by a rare inherited defect in this receptor (Glanzmann' s thrombasthenia), characterized by muco cutaneous and postsurgical bleeding, but infrequent spontaneous organ (particularly central nervous system) bleeding, suggested that therapeutic inhibition of this receptor might be a potent, yet well-tolerated means of treating thrombotic disorders.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 488 pp. Englisch. N° de réf. du vendeur 9781617374081
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Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease
Edité par
Humana Press, Humana Press, 2010
ISBN 10 : 1617374083
ISBN 13 : 9781617374081
Neuf
Taschenbuch
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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - A. Michael Lincoff takes advantage of critically important new knowledge arising from recent clinical trials to update and expand his acclaimed Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease. This substantially enhanced Second Edition contains new chapters on the role of GPIIb/IIIa blockade during acute coronary syndromes, on outcomes with chronic oral GPIIb/IIIa blockade following acute coronary syndromes, and on fibrinolytic therapy during acute myocardial infarctions. Additional enhancements include revised findings from the latest trials of GPIIb/IIIa inhibition during percutaneous coronary intervention, discussion of GPIIb/IIIa blockade with other platelet and thrombin inhibitors, and a review of the potential effects beyond inhibition of platelet aggregation. The book also explains the scientific basis of this therapy, evaluates its benefits and risks for patients, and summarizes detailed data from its various clinical trials. Comprehensive and definitive, Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease, Second Edition offers physicians, cardiologists, emergency room doctors, and basic scientists a complete and authoritative review of the state-of-the-art in glycoprotein IIb/IIIa receptor inhibitor use today. N° de réf. du vendeur 9781617374081
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