Protein Folding, Misfolding and Aggregation : Classical Themes and Novel Approaches

Victor Muñoz

ISBN 10: 0854042571 / ISBN 13: 9780854042579

Edité par RSC Publishing Jun 2008, 2008

A propos de cet article

Neuware - Protein folding is the process by which newly synthesized proteins fold into the specific three-dimensional structures defining their biologically active states while avoiding aggregation into pathogenic assemblies. It has always been a major focus of research in biochemistry and has often been seen as the unsolved second part of the genetic code. In the last 10 years we have witnessed a quantum leap in the research in this exciting area. Computational methods have improved to the extent of making it possible to simulate the complete folding process of small proteins and the early stages of protein aggregation. Experimental methods have evolved to permit resolution of fast processes of folding reactions and visualisation of single molecules during folding. As a result, the study of protein folding and aggregation has acquired a high level of technical and conceptual sophistication, in which theory, computer simulations and experiments are starting to be combined in a global approach. Protein Folding, Misfolding and Aggregation: Classical Themes and Novel Approaches includes chapters in the areas that have witnessed major developments and are written by top experts in the field. The book is unique in its scope and in its coverage of all the new developments in this area by filling a much needed gap in the current literature. Readers will obtain a unique perspective of the problems faced in the biophysical study of protein conformational behaviour in aqueous solution and how these problems are being solved with a multidisciplinary approach that combines theory, experiment, and computer simulations. RSC The book is essential reading for graduate and postdoctoral students actively involved in protein folding research, other scientists interested in the recent progress of the field, and instructors revamping the protein folding section of their biochemistry and biophysics courses.

N° de réf. du vendeur 9780854042579

Détails bibliographiques

• Titre: Protein Folding, Misfolding and Aggregation : Classical Themes and Novel Approaches
• Éditeur: RSC Publishing Jun 2008
• Date de parution: 2008
• Langue: anglais
• ISBN à 10 chiffres: 0854042571
• ISBN à 13 chiffres: 9780854042579
• Reliure: Buch
• État de l'article: Neu
• Dimensions: 241 L x 156 H x 22 P (en millimètres) 241 millimètres de largeur par 156 millimètres de hauteur par 22 millimètres de profondeur
• Poids: 590 grammes

A propos de ce titre

Synopsis

This unique book covers all the modern approaches and the many advances experienced in the field of protein folding and aggregation during the last 10 years.

À propos de l?auteur

Victor Mu±oz is Associate Professor in Chemistry and Biochemistry at the University of Maryland, USA and Research Professor in Biophysics at the Spanish Research Council (CSIC), Madrid, Spain. He has worked in the area of protein folding and aggregation for the last 16 years and for the last 7 years he has been involved in promoting a change from the classical biochemical to a physical paradigm in experimental protein folding.