G Protein Methods and Protocols: Role of G Proteins in Psychiatric and Neurological Disorders

. Ed(s): Mishra, Ram K.; Baker, Glen B.; Boulton, Alan A.

ISBN 10: 1489942904 / ISBN 13: 9781489942906

Edité par Humana, 2013

Editor(s): Mishra, Ram K.; Baker, Glen B.; Boulton, Alan A. Series: Neuromethods. Num Pages: 433 pages, 92 black & white illustrations, biography. BIC Classification: PSF. Category: (P) Professional & Vocational. Dimension: 229 x 152 x 23. Weight in Grams: 652. . 2013. Softcover reprint of the original 1st ed. 1997. paperback. . . . . Books ship from the US and Ireland. N° de réf. du vendeur V9781489942906

Synopsis :

The G proteins are a family of structurally homologous, plasma membrane-associated guanine-nucleotide-binding proteins. These proteins play an integral role in the tra- duction of extracellular signals through second messenger systems. As such, G proteins affect a wide variety of intra cellular biochemical reactions by regulating the concent- tion of second messengers in cells. G proteins are heterotrimeric, consisting of a, p, and y polypeptide chains, with G protein specificity largely det- mined by the a-subunit, Molecular cloning of G protein s- units has revealed 23 distinct a-subunits, encoded by 17 different genes. Based on functional measures, G proteins are generally classified into three major categories: the G, family, which is stimulatory for adenylyl cyclase; the G, f- ily, which is inhibitory for adenylyl cyclase; and the G, f- ily, which stimulates phospholipases (Birnbaumer and Birnbaumer, 1995). Alternatively, on the basis of sequence homology, G proteins can be subdivided into four cate- ries: G, G, G, and G12.

Détails bibliographiques

Titre : G Protein Methods and Protocols: Role of G ...
Éditeur : Humana
Date d'édition : 2013
Reliure : Couverture souple
Etat : New