Quantitative Health Risk Analysis Methods : Modeling the Human Health Impacts of Antibiotics Used in Food Animals

Louis Anthony Cox Jr.

ISBN 10: 1441938508 / ISBN 13: 9781441938503

Edité par Springer US, Springer US, 2010

A propos de cet article

Druck auf Anfrage Neuware - Printed after ordering - This book grew out of an effort to salvage a potentially useful idea for greatly simplifying traditional quantitative risk assessments of the human health consequences of using antibiotics in food animals. In 2001, the United States FDA's Center for Veterinary Medicine (CVM) (FDA-CVM, 2001) published a risk assessment model for potential adverse human health consequences of using a certain class of antibiotics, fluoroquinolones, to treat flocks of chickens with fatal respiratory disease caused by infectious bacteria. CVM's concern was that fluoroquinolones are also used in human medicine, raising the possibility that fluoroquinolone-resistant strains of bacteria selected by use of fluoroquinolones in chickens might infect humans and then prove resistant to treatment with human medicines in the same class of antibiotics, such as ciprofloxacin. As a foundation for its risk assessment model, CVM proposed a dramatically simple approach that skipped many of the steps in traditional risk assessment. The basic idea was to assume that human health risks were directly proportional to some suitably defined exposure metric. In symbols: Risk = K × Exposure, where 'Exposure' would be defined in terms of a metric such as total production of chicken contaminated with fluoroquinolone-resistant bacteria that might cause human illnesses, and 'Risk' would describe the expected number of cases per year of human illness due to fluoroquinolone-resistant bacterial infections caused by chicken and treated with fluoroquinolones.

N° de réf. du vendeur 9781441938503

Détails bibliographiques

• Titre: Quantitative Health Risk Analysis Methods : Modeling the Human Health Impacts of Antibiotics Used in Food Animals
• Éditeur: Springer US, Springer US
• Date de parution: 2010
• Langue: anglais
• ISBN à 10 chiffres: 1441938508
• ISBN à 13 chiffres: 9781441938503
• Reliure: Taschenbuch
• État de l'article: Neu
• Dimensions: 235 L x 155 H x 21 P (en millimètres) 235 millimètres de largeur par 155 millimètres de hauteur par 21 millimètres de profondeur
• Poids: 569 grammes

A propos de ce titre

Synopsis

Worldwide health care problems are finding growing application in Operations Research. This monograph covers a range of modeling and methodological issues including environmental, experimental, simulation, and mathematical modeling approaches. The author is one of the leading research scholars in the field. His work on health risk modeling will be synthesized along with the work of others on modeling human health risks. The main goal is to provide and illustrate methods for quantitative risk assessment and for comparing alternative risk management actions, given realistic limitations on scientific knowledge and available data. Some of the steps covered are hazard identification, exposure assessment, dose-response modeling, and risk characterization, including uncertainty and sensitivity analyses.

Présentation de l'éditeur

Worldwide health care problems are a hot, growing application in Operations Research. Along with a quickly growing field is an active community of Medical OR and Risk Analysis researchers. Tony Cox is one of the leading research scholars in the field of Risk Heath Risk. His work on health risk modeling will be synthesized along with the work of others on modeling human health risks. The monograph will cover a range of modeling and methodological issues including environmental, experimental, simulation, and mathematical modeling approaches.