Recoding: Expansion of Decoding Rules Enriches Gene Expression

John F. Atkins (u. a.)

ISBN 10: 0387893814 / ISBN 13: 9780387893815

Edité par Springer, 2009

Recoding: Expansion of Decoding Rules Enriches Gene Expression | John F. Atkins (u. a.) | Buch | Nucleic Acids and Molecular Biology | xx | Englisch | 2009 | Springer | EAN 9780387893815 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu Print on Demand. N° de réf. du vendeur 101685851

Synopsis :

The literature on recoding is scattered, so this superb book ?lls a need by prov- ing up-to-date, comprehensive, authoritative reviews of the many kinds of recoding phenomena. Between 1961 and 1966 my colleagues and I deciphered the genetic code in Escherichia coli and showed that the genetic code is the same in E. coli, Xenopus laevis, and guinea pig tissues. These results showed that the code has been c- served during evolution and strongly suggested that the code appeared very early during biological evolution, that all forms of life on earth descended from a c- mon ancestor, and thus that all forms of life on this planet are related to one another. The problem of biological time was solved by encoding information in DNA and retrieving the information for each new generation, for it is easier to make a new organism than it is to repair an aging, malfunctioning one. Subsequently, small modi?cations of the standard genetic code were found in certain organisms and in mitochondria. Mitochondrial DNA only encodes about 10-13 proteins, so some modi?cations of the genetic code are tolerated that pr- ably would be lethal if applied to the thousands of kinds of proteins encoded by genomic DNA.

Présentation de l'éditeur: The genetic code is dynamic? it, or its readout, can be specifically changed by mRNA signals that modify the behavior of on-board ribosomes. Many viruses use recoding to maximize utilization of information in small genomes, and probably all organisms use recoding in at least some genes for expanding the regulatory repertoire. The volume will detail specific recoding examples to understand the mechanisms and the mRNA signals. It will continue to detail the biochemical and genetic approaches to identify and study the cellular factors involved in recoding. The signals in mRNA that dictate recoding often include complex folded structures of the RNA, which we are studying by a combination of microbiology, genetics, biochemical and NMR approaches.

Détails bibliographiques

Titre : Recoding: Expansion of Decoding Rules ...
Éditeur : Springer
Date d'édition : 2009
Reliure : Buch
Etat : Neu