Research in Computational Molecular Biology

Terence Terry Speed

ISBN 10: 3540716807 / ISBN 13: 9783540716808

Edité par Springer, 2007

Abnutzung / Risse - leicht; Gebrochener Buchrücken / Seiten oder Softcover umgeknickt. The content covers a range of advanced methodologies and tools in the field of computational biology and bioinformatics. It includes techniques for querying protein interaction networks, aligning these networks through neighborhood topology, and reconstructing protein complex topologies. The concept of "Network Legos" is introduced as a means to build cellular wiring diagrams. Methods for dynamic analysis of gene regulatory networks and in silico gene perturbation experiments are discussed, along with a feature-based approach to modeling protein-DNA interactions. The annotation also highlights network motif discovery through subgraph enumeration and symmetry-breaking, and the enhancement of de novo motif discovery using nucleosome occupancy information. It presents frameworks for identifying DNA copy number aberrations and estimating genome-wide copy numbers with allele-specific mixture models. Statistical methods for analyzing whole-genome array CGH data are introduced, as well as new approximation methods for simulating enzymatic reactions. Further topics include learning MHC II-peptide binding, reconstructing phylogenies of mobile elements, and developing heuristics for gene-duplication problems. It discusses tools for RNA folding kinetics simulation, multiple sequence alignment techniques, and connectedness profiles in protein networks for gene expression analysis. A Bayesian model linking microarray and mass spectrometr. N° de réf. du vendeur 53ebf9a5-cfe4-4cca-b1a3-8923aa7b84a6

Synopsis :

This book constitutes the refereed proceedings of the 11th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2007, held in Oakland, CA, USA in April 2007. The 37 revised full papers address all current issues in algorithmic, theoretical, and experimental bioinformatics.

Présentation de l'éditeur: This book constitutes the refereed proceedings of the 11th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2007, held in Oakland, CA, USA in April 2007. The 37 revised full papers address all current issues in algorithmic, theoretical, and experimental bioinformatics.

Détails bibliographiques

Titre : Research in Computational Molecular Biology
Éditeur : Springer
Date d'édition : 2007
Reliure : Softcover
Etat : Fine