Solubility Enhancement of Certain Drugs by Solid Dispersion Technique

Vidyadhara Suryadevara (u. a.)

ISBN 10: 3659668346 / ISBN 13: 9783659668340

Edité par LAP LAMBERT Academic Publishing, 2015

Solubility Enhancement of Certain Drugs by Solid Dispersion Technique | Vidyadhara Suryadevara (u. a.) | Taschenbuch | 228 S. | Englisch | 2015 | LAP LAMBERT Academic Publishing | EAN 9783659668340 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. N° de réf. du vendeur 104924956

Synopsis :

Recent advances in novel drug delivery systems (NDDS) aim to enhance safety and efficacy of drug molecules by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach was fast dissolving tablets which have gained acceptance and popularity in the recent time. Several pharmaceutical industries prepared fast dissolving tablets by direct compression technique by selecting suitable super disintegrants. Direct compression technique offers important advantages such as increased output, reduced cost, less machinery and improved drug stability compared to wet granulation method.The aim of the work is to enhance the solubility, dissolution rate and oral bioavailability of poorly soluble drugs lovastatin and simvastatin by formulating them as solid dispersions using various techniques with PEG-6000 as a carrier and subsequent preparation of fast dissolving tablets with the prepared solid dispersions using different concentrations of super disintegrants and comparing them with that of the marketed product.

Présentation de l'éditeur: Recent advances in novel drug delivery systems (NDDS) aim to enhance safety and efficacy of drug molecules by formulating a convenient dosage form for administration and to achieve better patient compliance. One such approach was fast dissolving tablets which have gained acceptance and popularity in the recent time. Several pharmaceutical industries prepared fast dissolving tablets by direct compression technique by selecting suitable super disintegrants. Direct compression technique offers important advantages such as increased output, reduced cost, less machinery and improved drug stability compared to wet granulation method.The aim of the work is to enhance the solubility, dissolution rate and oral bioavailability of poorly soluble drugs lovastatin and simvastatin by formulating them as solid dispersions using various techniques with PEG-6000 as a carrier and subsequent preparation of fast dissolving tablets with the prepared solid dispersions using different concentrations of super disintegrants and comparing them with that of the marketed product.

Détails bibliographiques

Titre : Solubility Enhancement of Certain Drugs by ...
Éditeur : LAP LAMBERT Academic Publishing
Date d'édition : 2015
Reliure : Taschenbuch
Etat : Neu