Stem Cell Therapy for Neurodegenerative Disorders: Mechanisms, Applications, and Advances

This book comprehensively reviews the role of stem cell therapy against various neurodegenerative disorders. The initial chapters present different neurodegenerative disorders and discuss the application of stem cell therapy for Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis (ALS), and Huntington's Disease. Aging and its impact on neurodegenerative disorders are also covered, addressing neuronal dysfunctions with age, neuromuscular dysfunctions like sarcopenia and frailty, and the potential role of stem interventions in aging. The subsequent section provides an overview of the different types of therapies, including cell replacement and neuroprotection. It also covers clinical trials of stem cell therapies for neurodegenerative disorders and discusses the advantages and disadvantages of various stem cell types and delivery methods. Further, the book explores the mechanisms of action, detailing how stem cells induce neural regeneration and repair. It also examines their role in reducing inflammation and oxidative stress, alongside potential risks and safety concerns associated with stem cell therapies. Towards the end, the book presents advanced delivery systems for stem cell therapies, the therapeutic potential of stem cell-derived exosomes and microvesicles in neurodegeneration, preclinical studies in animal models, and the role of organoids in neurodegenerative disorders. This book is useful for researchers and students of neuroscience, neurology, stem cell, pharmaceutical sciences, and biotechnology.

Key Features

· Provides an in-depth review of stem cell therapy for various neurodegenerative disorders, including Alzheimer's, Parkinson's, ALS, and Huntington's Disease.

· Addresses aging-related neuronal and neuromuscular dysfunctions, such as sarcopenia and frailty.

· Offers a detailed analysis of different types of stem cell-based therapies, including cell replacement and neuroprotection.

· Covers clinical trials of stem cell therapies for neurodegenerative disorders, discussing the advantages and disadvantages of various stem cell types.

· Explores the mechanisms by which stem cells promote neural regeneration and repair, reduce inflammation, and oxidative stress

· Discusses cutting-edge delivery systems for stem cell therapies, enhancing the effectiveness and precision of treatments

This book is useful for researchers and students of neuroscience, neurology, stem cell, pharmaceutical sciences, and biotechnology.

Masroor Anwar is a Scientist D in the Department of Biophysics at the All India Institute of Medical Sciences, New Delhi. His research focuses on aging and age-related diseases, specifically skeletal muscle regeneration and muscle stem cell biology. He has also a keen interest in mesenchymal stem cell regeneration. Currently, Dr. Anwar is working on neurodegenerative diseases, including Alzheimer’s and dementia. He has published several research articles in high-impact international journals and serves on the editorial boards of several journals.

Misbahuddin M. Rafeeq is an Associate Professor in the Department of Pharmacology at the Faculty of Medicine (Rabigh), King Abdulaziz University, Saudi Arabia. He completed his MBBS and MD in Pharmacology from Aligarh Muslim University, India. Dr. Rafeeq serves on the editorial boards of several other journals. He has received numerous awards and fellowships, including the Excellent Leadership Award from IDB, Saudi Arabia, and the Distinguished Achievement Award from KAU, Saudi Arabia. His research focuses on identifying novel genetic mutations in hereditary syndromes, exploring therapeutic targets through molecular docking, PK/PD, and toxicity studies, and studying the effects of natural compounds on animal models. Dr. Rafeeq has more than sixty-five high-impact publications and has secured funding for several large grants as a Principal/Co-Investigator.

Mukhtiar Baig is a distinguished Professor of Clinical Biochemistry and Medical Educationist, currently serving as the Coordinator of the Assessment Unit at the Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, KSA. He holds multiple advanced degrees, including an MBBS from Liaquat Medical College, an MPhil and Ph.D. in Biochemistry from the University of Karachi, and an MHPE from Dow University of Health Sciences. Dr. Baig has been globally recognized, being included in Stanford University’s list of the top 2% of scientists worldwide for 2022 and 2023. He has authored 160 international refereed publications and contributed to seven book chapters. Dr. Baig’s research interests cover clinical biochemistry, identification of genetic mutations, and the effects of natural compounds on animal models.