Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy: A Comprehensive Guide

This new edition is a fully updated, comprehensive review of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT): its physics, clinical evidence, indications, and future directions. The utilization of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) is increasing internationally because of several factors. First, it offers patients a local treatment option that has demonstrated effectiveness similar to traditional surgery without the morbidity of general anesthesia and open surgical resection. Second, recent advancements in the quality of scientific evidence supporting a SRS or SBRT-containing approach in patients continues to evolve and demonstrate favorable disease-specific outcomes with little, if any, toxicity in various anatomic disease sites and for various conditions including cancer, benign tumors, and other psychiatric and neurologic conditions. Third, and most provocatively, is the notion that definitive local therapy (i.e. SRS or SBRT) in patients with cancer can boost the immune system to fight cancer in other sites throughout the body. While traditional medical knowledge would suggest that all patients with metastatic cancer are incurable, there is a mounting body of evidence that there is a subset of these patients that can be cured with definitive SRS or SBRT. This volume thus delves into each of these benefits and aspects of treatment, guiding physicians to the best treatment plan for their patients.

Expert, international authors provide guidelines for SRS and SBRT use by clinicians. Chapters are divided into six main sections: Radiobiology of Radiosurgery and Stereotactic Body Radiation Therapy, Intracranial Radiosurgery Technique, Intracranial Radiosurgery by Indication, Stereotactic Body Radiation Therapy Technique, Stereotactic Body Radiation Therapy by Indication, The Future of Radiosurgery and SBRT. Overall physics are explained, as well as specific considerations for particular surgical tools (including the Leksell Gamma Knife and Accuray CyberKnife), techniques (including fractionated and charged particle radiosurgery), and anatomic sites (including brain metastases, pituitary tumors, and the prostate). Since the first edition published, the field has grown significantly. There is now significant new data to support preoperative radiosurgery, increased indications in metastatic cancers, as well as integration with new drug therapies and imaging techniques. Each chapter is thus fully updated with the latest in medical advancements and new scientific research. Detailed images and charts enhance the chapters.

This book provides physicians with a single, practical resource incorporating both of these broad categories of treatment, SRS and SBRT, and better defines the current role and the direction of radiosurgery.

Daniel M. Trifiletti, MD is a Professor of Radiation Oncology at The Mayo Clinic. He has won a number of awards related to his work in radiation oncology and has published extensively.

Samuel T. Chao, MD, FASTRO is a Professor in the Department of Radiation Oncology and the Brain Tumor and Neuro-Oncology Center at the Cleveland Clinic. He is also Director of CNS Radiation Oncology, Head of the Center for Cerebral Radiation Necrosis, Associate Director of the Gamma Knife Center, and Vice Chair of Quality and Safety in Radiation Oncology.

Arjun Sahgal, MD, FRCPC is an Associate Professor in the Department of Radiation Oncology and Surgery at the University of Toronto.

Jason P. Sheehan, MD, PhD is a Professor of Neurological Surgery, Radiation Oncology, Biomedical Engineering and Neuroscience, and the Harrison Distinguished Teaching Chair of Neurosurgery at The University of Virginia, Health Sciences Center. There he is also the Neuroscience and Behavioral Science Medicine Service Line Director, Vice Chair of Academic Affairs in Neurological Surgery, Director of the Lars Leksell Gamma Knife Center, Co-Director of the UVa-Mary Washington Radiosurgery Center, Associate Residency Program Director, Director of Spinal Radiosurgery, and Co-medical Director of the UVa-Riverside Radiosurgery Center. He has published extensively in radiation oncology.