Structure-based Ligand Design (Methods and Principles in Medicinal Chemistry)

ISBN 10: 3527293434 / ISBN 13: 9783527293438

Edité par Wiley-VCH, 1998

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Synopsis :

Although emerging only since the 1980s, structure-based drug design has already become a powerful tool for commercial drug design. Much has been learned, however, since the first attempts to develop drugs on the basis of available biochemical and structural data. This volume, besides presenting the underlying principles and foundations of the approach, describes real-life applications. It shows that structure-based drug design, if employed properly and with a thorough knowledge of the pitfalls to avoid, is superior to the traditional approach of designing new drugs and can thus save large amounts of time and money. The presentation and many references to the original literature, as well as numerous colour figures illustrating structural relationships, should make this volume a tool for scientists working in the area of drug design.

Présentation de l'éditeur: Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure–based ligand design. Although this method first emerged in the 1980s, it has already become a powerful tool for pharmaceutical research. Much has been learned, however, since the first attempts to discover drugs on the basis of available biochemical and structural data. Nowadays, structure–based ligand design is an established method for creating drugs with new structural features, for modifying binding activities and pharmacokinetic properties, and for elucidating binding modes and structure–activity relationships.

This volume presents the underlying principles of the approach and highlights real–life applications such as the discovery of HIV–protease inhibitors. It shows that structure–based ligand design has many advantages over other more traditional approaches to designing new drugs, providing it is employed properly and with a thorough knowledge of the pitfalls to avoid.

The straightforward presentation and extensive list of references to the original literature as well as numerous color figures illustrating structural relationships make this volume an indispensable tool for every scientist working in the area of drug discovery.

Détails bibliographiques

Titre : Structure-based Ligand Design (Methods and ...
Éditeur : Wiley-VCH
Date d'édition : 1998
Reliure : Hardcover
Etat : Very Good
Etat de la jaquette : Jaquette
Type de livre : book