Synthesis & Evaluation of 2&6-Substituted 4H-Chromen-4-One Derivatives

Chirag J. Patel

ISBN 10: 3659345490 / ISBN 13: 9783659345494

Edité par LAP LAMBERT Academic Publishing Feb 2013, 2013

A propos de cet article

Neuware -The present investigation is concerned with synthesis of new 2 and 6 - substituted 4H-chromen-4-One derivatives with the objectives of discovering novel and potent anti-inflammatory agents and anti-oxidants. The results of anti-inflammatory activity were revealed that the compound has indole 2 substitution with 4-nitrophenyl amino methyl (at 6th position) on 4H- chromen¿4¿one having more anti-inflammatory activity as compared to other substituent¿s. While, indole 2 substituted 4-methoxy phenyl amino methyl (at 6th position) 4H¿chromen¿4¿one showed outperformed anti-oxidant activity in different anti-oxidant model as compared to other substituent¿s. The all newly synthesized compounds displayed moderate to potent anti-inflammatory and anti-oxidant activity and has therapeutic potential in combating this devastating inflammatory and oxidative condition of the body, might be deserve promising substances for further in vivo evaluation as anti-inflammatory and anti-oxidant properties. However the anti-inflammatory activity is not related to antioxidant potential.Books on Demand GmbH, Überseering 33, 22297 Hamburg 100 pp. Englisch.

N° de réf. du vendeur 9783659345494

Détails bibliographiques

• Titre: Synthesis & Evaluation of 2&6-Substituted 4H-Chromen-4-One Derivatives
• Éditeur: LAP LAMBERT Academic Publishing Feb 2013
• Date de parution: 2013
• Langue: anglais
• ISBN à 10 chiffres: 3659345490
• ISBN à 13 chiffres: 9783659345494
• Reliure: Taschenbuch
• État de l'article: Neu

A propos de ce titre

Synopsis

The present investigation is concerned with synthesis of new 2 and 6 - substituted 4H-chromen-4-One derivatives with the objectives of discovering novel and potent anti-inflammatory agents and anti-oxidants. The results of anti-inflammatory activity were revealed that the compound has indole 2 substitution with 4-nitrophenyl amino methyl (at 6th position) on 4H- chromen–4–one having more anti-inflammatory activity as compared to other substituent’s. While, indole 2 substituted 4-methoxy phenyl amino methyl (at 6th position) 4H–chromen–4–one showed outperformed anti-oxidant activity in different anti-oxidant model as compared to other substituent’s. The all newly synthesized compounds displayed moderate to potent anti-inflammatory and anti-oxidant activity and has therapeutic potential in combating this devastating inflammatory and oxidative condition of the body, might be deserve promising substances for further in vivo evaluation as anti-inflammatory and anti-oxidant properties. However the anti-inflammatory activity is not related to antioxidant potential.

À propos de l?auteur

Prof. Chirag J. Patel, Ph.D. fellow in Pharmaceutical Sciences at K.S.K.V. Kachchh University, Bhuj-Kachchh, Gujarat, INDIA. Field of Study: Phytopharmacoligal Screening of Some Laticiferous Plants & Drug Design with Development. Presently working as an Associate Professor at Veerayatan Institute of Pharmacy, India from last seven years.