Titre: Taste Mask Orodispersible Tablet of Metronidazole: Development and Characterization of taste mask Orodispersible tablets of Metronidazole
�diteur: LAP LAMBERT Academic Publishing
Date de parution: 2012
Langue: anglais
ISBN � 10 chiffres: 3848442973
ISBN � 13 chiffres: 9783848442973
Reliure: Couverture souple
�tat de l'article: New

A propos de ce titre

Synopsis

Patients who have problems in swallowing encounter difficulties in taking tablets, particularly pediatric and geriatric patients. Such problems can be resolved by means of orodispersible tablets. These tablets disintegrate instantaneously when put on tongue, releasing the drug that dissolves or disperses in the saliva.Metronidazole is active against a wide variety of anaerobic protozoal parasites and anaerobic bacteria.The present study aim to prepare tablets that can rapidly disintegrate in oral cavity (orodispersible), another challenge with this model drug is to mask the bitter taste. Taste masking was achieved by using aminoalkyl methacrylate copolymer (Eudragit E-100) in the different ratio (1:2 and 1:3) by extrusion technique. The IR shows that there was no significant evidence for interaction between drug and polymers. Six formulations were prepared using taste masked granules and different disintegrants (LH-11) and Avicel PH-102 by varying concentration.